uspto-grants-2015_09 · 10.6084/m9.figshare.5104873.v1 · US09125814B2
查看IDENTITY
结构与身份
- 标准SMILES
- CCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C.Cl
- InChIKey
- NDNSIBYYUOEUSV-RSAXXLAASA-N
- 分子式
- C17H27ClN2O
- 平均分子量
- 310.9 g/mol
- 单同位素质量
- 310.1811912
COMPUTED
结构计算性质
- 极性表面积
- 32.3 Ų
- 氢键供体
- 2
- 氢键受体
- 2
- 可旋转键
- 4
- 重原子
- 21
- 形式电荷
- 0
- 复杂度
- 308
GHS
GHS分类
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral];H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation];H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
PHARMACOLOGY
药理信息
FDA Pharmacological Classification
ROPIVACAINE HYDROCHLORIDE
Amide Local Anesthetic [EPC]; Amides [CS]; Local Anesthesia [PE]
MeSH Pharmacological Classification
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
ALIASES
名称与别名
REACTIONS