Acetic Acid

Aqueous solution 1.0 molar = 2.4; 0.1 molar = 2.9; 0.01 molar = 3.4

-0.17

log Kow = -0.17

-0.17

-0.17

1.22

Pungent

Sour, vinegar-like odor

Burning taste

1.051 at 68 °F (USCG, 1999) - Denser than water; will sink

1.0446 g/cu cm at 25 °C

Density: 1.266 at 16.60 °C (solid); 1.053 at 16.67 °C (liquid); contracts slightly on freezing

Relative density (water = 1): 1.05

1.049

1.05

1.056 mPa-s at 25 °C

Clear, colorless liquid

Colorless liquid or crystals (Note: Pure compound is a solid below 62 degrees F). Often used in an aqueous solution).

greater than or equal to 100 mg/mL at 73 °F (NTP, 1992)

1000000

Miscible with water

Miscible with ethanol, ethyl ether, acetone, benzene; soluble in carbon tetrachloride, carbon disulfide

Miscible with glycerol; insoluble in carbon disulfide

1000.0 mg/mL

Corrosive organic acid

Glacial acetic acid (100%) is highly corrosive, and its ingestion has produced penetrating lesions of the esophagus and later strictures of the esophagus and pylorus in man.

104 °F (NTP, 1992)

103 °F (NFPA, 2010)

The Guide from the Emergency Response Guidebook is for "acetic acid, glacial." 39 °C

103 °F (39 °C) Closed cup

112 °F (open cup); 104 °F (closed cup)

39 °C c.c.

244 °F at 760 mmHg (NTP, 1992)

117.9

117.9 °C

118 °C

118 °C

244 °F

Danger

H226: Flammable liquid and vapor [Warning Flammable liquids]；H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (3 of 5076) of reports.

Chemical: Acetic acid

Commission Regulation (EU) No 231/2012 (amended)

Acetic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

2008/127, Reg. (EU) 2017/195, Reg. (EU) 2022/708, Reg. (EU) 2023/1446, Reg. (EU) No 540/2011, Reg. (EU) No 790/2013

Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15549

Acetic acid: Does not have an individual approval but may be used under an appropriate group standard

IMAP assessments - Acetic acid: Environment tier I assessment；IMAP assessments - Acetic acid: Human health tier II assessment

Corrosive Flammable Liquid

Corrosive

Corrosive Flammable Liquid

Special Hazards of Combustion Products: Irritating vapor generated when heated. (USCG, 1999)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:；Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Corrosives in contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2024)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:；Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids will float on water. (ERG, 2024)

· Flammable/combustible material.；· May be ignited by heat, sparks or flames.；· Vapors may form explosive mixtures with air.；· Vapors may travel to source of ignition and flash back.；· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).；· Vapor explosion hazard indoors, outdoors or in sewers.；· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.；· Runoff to sewer may create fire or explosion hazard.；· Containers may explode when heated.；· Many liquids will float on water.

Flammable. Above 39 °C explosive vapour/air mixtures may be formed. Risk of fire and explosion on contact with strong oxidants.

Moderate fire risk.

Breathing of vapors causes coughing, chest pain, and irritation of nose and throat; may cause nausea andvomiting. Contact with skin and eye causes burns. (USCG, 1999)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:；TOXIC and/or CORROSIVE; inhalation, ingestion or skin contact with material may cause severe injury or death. Methyl bromoacetate (UN2643) is an eye irritant/lachrymator (causes flow of tears). Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. (ERG, 2024)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:；May cause toxic effects if inhaled or ingested. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas. Runoff from fire control or dilution water may cause environmental contamination. (ERG, 2024)

· May cause toxic effects if inhaled or ingested.；· Contact with substance may cause severe burns to skin and eyes.；· Fire will produce irritating, corrosive and/or toxic gases.；· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.；· Runoff from fire control or dilution water may cause environmental contamination.

Liquid causes second degree burns after contact for a few minutes; [CHRIS] Highly corrosive to skin; [Quick CPC] Glacial refers to a number of acids, e.g., acetic and phosphoric, which have a freezing point slightly below room temperature when in a highly pure state. For example, glacial acetic acid is 99.8% pure and crystallizes at 16.6 C. [Hawley] Household vinegar is usually a 5% solution. Use skin protection if >10% solution of acetic acid. The vapor can cause lacrimation. [HSDB] A case of RADS and a case of asthma caused by glacial acetic acid have been reported in the medical literature. [Rajan, 1989; Kivity, 1994] Pulmonary edema may result from inhalation of high concentrations. [NJ-HSFS]

2789 132

2790 153(10-80% acid)

2789 132(>80% acid)

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl acetic acid, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including acetic acid, glacial, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Acetic acid used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: Acetic acid is included in topical otic drug products.

Acids, Carboxylic

Acids, Carboxylic；Water and Aqueous Solutions

Acids, Carboxylic；Water and Aqueous Solutions

Symbol: C; R: 10-35; S: (1/2)-23-26-45; Note: B

UN Hazard Class: 8; UN Subsidiary Risks: 3; UN Pack Group: II

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:；Some of these materials may react violently with water.；SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.；LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.；FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:；SMALL FIRE: Dry chemical, CO2 or water spray.；LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.；FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:；Some of these materials may react violently with water.；SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.；LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.；FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use powder, alcohol-resistant foam, water spray, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. If within a few minutes after ingestion, one small glass of water may be given to drink. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.；· Keep unauthorized personnel away.；· Stay upwind, uphill and/or upstream.；· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.；· All equipment used when handling the product must be grounded.；· Do not touch or walk through spilled material.；· Stop leak if you can do it without risk.；· Prevent entry into waterways, sewers, basements or confined areas.；· A vapor-suppressing foam may be used to reduce vapors.；· Absorb with earth, sand or other non-combustible material.；· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).；· Use clean, non-sparking tools to collect absorbed material.；Large Spill；· Dike far ahead of liquid spill for later disposal.；· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:；Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. Removal of solidified molten material from skin requires medical assistance. (ERG, 2024)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:；Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)

General First Aid:；· Call 911 or emergency medical service.；· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.；· Move victim to fresh air if it can be done safely.；· Administer oxygen if breathing is difficult.；· If victim is not breathing:；-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.；-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).；-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.；· Remove and isolate contaminated clothing and shoes.；· For minor skin contact, avoid spreading material on unaffected skin.；· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.；· For severe burns, immediate medical attention is required.；· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.；· Keep victim calm and warm.；· Keep victim under observation.；· For further assistance, contact your local Poison Control Center.；· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.；Specific First Aid:；· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

(General first aid procedures)；Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.；Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.；Breathing: Respiratory support；Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Fireproof. Separated from food and feedstuffs, strong oxidants, strong acids and strong bases. Store only in original container. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.

Advice for firefighters: wear self contained breathing apparatus for fire fighting. ...

Combustion may produce irritants and toxic gases.

· Wear positive pressure self-contained breathing apparatus (SCBA).；· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.；· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

163.0 [ppm]

10.0 [ppm]

Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water to keep fire-exposed containers cool.

/When fighting fire/ use self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.

Store in a dry, well-ventilated place. Separate from oxidizing materials and alkaline substances.

Fireproof. Separate from food and feedstuffs. Keep in a well-ventilated room.

... Quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.

Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid with sodium carbonate only under the responsibility of an expert. Wash away remainder with plenty of water (extra personal protection: chemical protection suit including self-contained breathing apparatus).

Remove all ignition sources, ventilate area of spill or leak. If in liquid form, for small quantities, absorb on paper towels ... large quantities can be collected & atomized in suitable combustion chamber, or diluted ... neutralized & flushed into a sewer. If in the solid form, collect in the most safe & convenient manner for reclamation or allow to melt & collect as above.

Methods and materials for containment and cleaning up: soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Contain spillage, soak up with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and transfer to a container for disposal according to local/national regulations.

Environmental precautions: prevent further leakage or spillage if safe to do so. Do not let product enter drains.

For more Cleanup Methods (Complete) data for ACETIC ACID (7 total), please visit the HSDB record page.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:；ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.；LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:；ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:；ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.；LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: dispose of as unused product.

Acetic acid was qualitatively detected in 2 of 12 human milk samples collected from volunteers in four US cities(1). Acetic acid at 19.9 mg/day was measured from non-specified human emissions(2). Humans exude <90mg/day of volatile fatty acids in exhaled breath and perspiration, 80% of which is acetic acid(3); in a confined environment, as much as 15-20 mg/cu m can accumulate and such concentrations can become serious in submarines or space capsules(3).

In cases of skin or eye exposure, the area should be flushed with water and burns covered with dry, sterile dressings after decontamination. If ingested, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution. Watch for signs of respiratory insufficiency and assist respiration if necessary. (A569)

Pain increases the rate, frequency, or intensity of some behaviors (eg, withdrawal responses) and suppresses other behaviors (eg, feeding). /The study is/ developing assays to test analgesic drug candidates using measurements of pain-suppressed rather than pain-elicited behaviors. Such assays may model important aspects of clinical pain and provide a means for distinguishing true analgesics from drugs that produce motor impairment. The present study compared effects of the mu opioid analgesic morphine and the nonanalgesic neuroleptic haloperidol on intraperitoneal acetic acid-induced writhing (a pain-elicited behavior) and suppression of feeding behavior (a pain-suppressed behavior). In feeding studies, C57BL/6J mice were given access to a dish containing 8 mL Ensure (trade mark) liquid food (0-100% in water) during daily sessions (7.5-120 min). Levels of consumption were dependent on both Ensure concentration and session duration. Intraperitoneal injection of acetic acid (0.10-0.56%) produced a time- and concentration-dependent decrease in Ensure consumption. Morphine (1 mg/kg) prevented both acid-induced writhing and acid-induced suppression of feeding, whereas the dopamine antagonist haloperidol inhibited writhing without preventing acid-induced suppression of feeding. The effects of morphine were time-dependent, selective for acid-suppressed feeding, and naltrexone-reversible. These results suggest that assays of pain-suppressed behaviors may complement assays of pain-elicited behaviors in preclinical studies of candidate analgesics...

Amylin is a member of calcitonin or calcitonin gene-related peptide (CGRP) family. Immunohistochemical study revealed a dense network of amylin-immunoreactive (irAMY) cell processes in the superficial dorsal horn of the mice. Numerous dorsal root ganglion (DRG) and trigeminal ganglion cells expressed moderate to strong irAMY. Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed amylin receptor mRNA in the mouse spinal cord, brain stem, cortex, hypothalamus and hippocampus. The nociceptive or antinociceptive effects of amylin were evaluated in the acetic acid-induced writhing test. Amylin (0.1, 0.5 and 1 mg/kg, intraperitoneally (i.p.) or 1-10 microg, intrathecally (i.t.)) reduced the number of writhes in a dose-dependent manner. Pretreatment of the mice with the amylin receptor antagonist salmon calcitonin (8-32), either by i.p. or i.t., antagonized the effect of amylin on acetic acid-induced writhing test. Locomotor activity was not significantly modified by amylin injected either i.p. (0.01-1 mg/kg) or i.t. (1-10 microg). Measurement of c-fos mRNA by RT-PCR or proteins by Western blot showed that the levels were upregulated in the spinal cord of mice injected with acetic acid and the increase was attenuated by pretreatment with amylin (10 microg, i.t.). Collectively, /these/ result demonstrates that irAMY is expressed in DRG neurons with their cell processes projecting to the superficial layers of the dorsal horn, and that the peptide by interacting with amylin receptors in the spinal cord may be antinociceptive.

INTRODUCTION: Increased free-radical production, decreased antioxidant capacity, and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals. Melatonin has also been shown to have anti-inflammatory activities in tissues. /This/ study objective is to investigate the effects of melatonin on tissue inflammatory activities using an ulcerative colitis (UC) model induced by acetic acid (AA) in rats. METHODS: Wistar rats (n = 32) were divided into four groups. AA-induced colitis was performed in two of the groups, while the other two groups were injected with saline intrarectally. One of the AA-induced colitis groups and one of the control groups were administered 100 mg/kg/day melatonin intraperitoneally, and the pair groups were given saline. After 4 days, colonic changes were evaluated biochemically by measuring proinflammatory cytokines [tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6], myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels in tissue homogenates and by histopathological examination. RESULTS: AA caused colonic mucosal injury, whereas melatonin suppressed these changes in the AA-induced colitis group (P < 0.001). AA administration resulted in increased TNF-alpha, IL-1beta, IL-6, MPO, and MDA levels, and decreased GSH and SOD levels, whereas melatonin administration reversed these effects (all P < 0.001). CONCLUSIONS: The present study proposes that melatonin has a dual action as an effective anti-inflammatory and an antioxidant, and may be a hopeful therapeutic agent for UC.

In the present study, the effect of chronic oral administration of curcumin in the presence or absence of morphine and noloxone was investigated on the visceral nociception induced by acetic acid in rats. Intraperitoneal injection of acetic acid (1 mL, 2%) produced contractions in the abdominal musculature (writhes). The latency time to the beginning of the first writhe was measured and the total number of writhes in the 1 hr after acetic acid injection was counted. The latency time to the beginning of the first writhe was significantly (p < 0.05) increased and the number of writhes was significantly (p < 0.05) decreased by curcumin (20 and 40 mg/kg body weight). The same results were obtained after subcutaneous injection of morphine (1 mg/kg b.wt.). Naloxone at the dose of 1 mg/kg body weight had no effect on pain intensity. Curcumin significantly (p < 0.05) enhanced the effect of morphine on the visceral pain responses, however did not reverse the effect of naloxone. Present data suggest that in the acetic acid-induced visceral nociception of rats, curcumin may produce an antinociceptive effect and the endogenous analgesic opioid system is involved in the curcumin-induced antinociception.

Nine out bred white male rats weighing approximately 100 g were used in /this/ study. Rats were given either N-nitrosarcosin ethyl ester (NSEE) alone, NSEE with the acetic acid solution, or the acetic acid solution alone. doses (0.5 mL of 3% water solution of acetic acid (about 60 mg/kg bw/treatment) were given by intubation into the esophagus 3 times per week. Animals were killed by ether inhalation after 8 months of experiments and autopsied. As expected, rats treated with the carcinogen NSEE had high incidences of pre-neoplastic lesions of the esophagus and forestomach, as well as benign tumors, carcinomas and squamous cell cancer. Prolonged administration of acetic acid in combination with NSEE resulted in an increase in the number of benign and malignant tumors and carcinomas in the esophagus. Prolonged administration of acetic acid alone did not induce tumors. All nine of these rats, however, did experience hyperplasia in the esophagus and forestomach.

Eyes, skin, respiratory system, teeth

Concentrated acetic acid is corrosive and can cause skin burns, permanent eye damage, and irritation to the mucous membranes. Ingestion can cause severe damage to the digestive system and a potentially lethal change in the acidity of the blood. (L1885)

EC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 156000 ug/L for 24 hr; Effect: physiology, assimilation efficiency /formulation/

LC50; Species: Crangon septemspinosa (Bay Shrimp, Sand Shrimp) weight 0.003 g; Conditions: saltwater, renewal, 15 °C, pH 3.64-8.07; Concentration: 116000 ug/L for 14 days (95% confidence interval: 85900-157000 ug/L) /99.7% purity/

LC50; Species: Crangon septemspinosa (Bay Shrimp, Sand Shrimp) weight 0.003 g; Conditions: saltwater, static, 15 °C, pH 2.26-7.96; Concentration: 158000 ug/L for 96 hr (95% confidence interval: 50000-500000 ug/L) /99.7% purity/

EC50; Species: Daphnia magna (Water flea); Conditions: static bioassay, neutralized to pH 8.0 and 20 °C; Concentration: 6,000 mg/L for 24 hr; Effect: immobilization

For more Ecotoxicity Values (Complete) data for ACETIC ACID (25 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an experimentally derived Koc value of 1.0(2,3), indicates that acetic acid is expected to have very high mobility in soil(SRC). No detectable sorption was measured for acetic acid using the OECD Guideline 106 method in three different soils(4). The pKa of acetic acid is 4.76(5), indicating that this compound will exist predominantly in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). Volatilization of acetic acid from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.43X10-7 atm-cu m/mole(7). Acetic acid is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 15.7 mm Hg at 25 °C(8). Using a modified Organization of Economic Cooperation and Development (OECD) protocol, 75% degradation was reported in 14 days using garden soil as an inoculum(9), indicating that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), a Koc value of 1.0(2,3), indicates that acetic acid is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 1.43X10-7 atm-cu m/mole(5). The pKa of acetic acid is 4.76(6), indicating that this compound will exist predominantly in anion form at an environmental pH range of 5-9. According to a classification scheme(7), an estimated BCF of 3(SRC), from its log Kow of -0.71(8) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis is not expected to be an important environmental fate process(SRC) since this compound lacks functional groups that hydrolyze under environmental conditions(4). Utilizing the Japanese MITI test, a 74% of theoretical BOD in 2 weeks using activated sludge(10) indicates that biodegradation is an important environmenal fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), acetic acid, which has a vapor pressure of 15.7 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. The pure compound is a solid below 68 °F(3). Particulate-phase acetic acid will be removed from the atmosphere by wet and dry deposition. Vapor-phase acetic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 22 days(SRC), calculated from its measured rate constant of 7.4X10-13 cu cm/molecule-sec at 25 °C(4). Particulate-phase acetic acid will be removed from the atmosphere by wet and dry deposition. Acetic acid does not absorb light with wavelengths >290 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Acetic acid occurs in rainwater, cloud water and fog(6-8) and can be removed from the atmosphere by wet deposition(SRC).

Acetic acid was identified as the major volatile constituent of commercial brown sugars(1); concentrations ranging from 31-827 ppm were detected in 26 brown sugars collected worldwide(1). The source of the acetic acid was found to be bacterial action in recycled sweet waters containing low levels of sucrose(1). Acetic acid was qualitatively detected as a volatile component of fried bacon, smoked pork, baked potatoes, soy sauce, roasted filbert nuts and frankfurters(2-6). Mean acetic acid concentrations of 39.6-116.6 were detected in several honeydew honey extracts(7).

Acetic acid was measured as a volatile compound in popped popcorn at a concentration of 4000 ug/kg(1), and in the extract of edible Korean chamchwi(2), cured pork(3), and volatiles from boiled short-necked clams, clams, and corbicula(4) at unreported concentrations. Volatile compounds from Bisbee Delicious apples included acetic acid present at concentrations from 25.6 to 3505.0 picoliter/kg-hr depending on the date of harvest(5). Acetic acid was reported in 7 different wines, ciders, and dessert wines and brandies from Germany at concentrations from 80 to 363 mg/L(6).

Twenty-two acids in ground roast coffees and instant coffees were determined by GLC (gas liquid chromatography) of their silyl derivatives (after preseparation by gel electrophoresis or isotachophoresis). The contribution to the total acidity (which was estimated by titration to pH 8 after cation exchange of the coffee solutions) was calculated for each individual acid. The acids contribute 67% (roast coffee) and 72% (instant coffee) to the total acidity. Citric acid (12.2% in roast coffee/10.7% in instant coffee), acetic acid (11.2%/8.8%) and the high MW acids (8%/9%) contribute to the total acidity.

Dermatotoxin - Skin burns.；Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.；Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Serious local effects by all routes of exposure.

inhalation, skin and/or eye contact

Oral (L1886) ; ihalation (L1886) ; ingestion (L1886)

Acetic acid was qualitatively detected in 2 of 12 human milk samples collected from volunteers in four US cities(1).

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

IDENTIFICATION AND USE: Acetic acid is a colorless liquid or solid, having a pungent characteristic odor, and when diluted in water an acidic taste. Glacial acetic acid is a 99% active chemical. It is used as an acidifier, flavoring agent, for the prevention of rope in baking, and as a solvent. Acetic acid is used as a laboratory reagent in chemical and biochemical analysis, in field testing of lead fumes, vinyl chloride determination, uric acid in urine, aniline vapors, and separation of gases. In addition, acetic acid is used in pesticide formulations as a herbicide to controls weeds on fruits, vegetables, ornamentals and turf. It is also a component of the hydraulic fracturing fluids preventing precipitation of metal oxides (iron control). Registered for use in the U.S., but approved pesticide uses may change periodically, so federal, state and local authorities must be consulted for currently approved uses. Three to 5% acetic acid is commonly used in the field of gynecology for colposcopic examinations of the cervix. It gives an 'acetowhite' effect that may assist clinicians in identifying neoplastic areas. HUMAN EXPOSURE AND TOXICITY: Acetic acid is absorbed from the gastrointestinal tract and through the lungs and almost completely oxidized by tissues. The metabolic pathways are reasonably well known and involve the formation of ketone bodies. As little as 1.0 mL of glacial acetic acid has resulted in perforation of the esophagus. During acetic acid dialysis, patients showed a frequent onset of sudden hypotension and arrhythmia with concomitant symptoms of the so-called disequilibrium syndrome. Extreme eye and nasal irritation has occurred at concentrations in excess of 25 ppm and conjunctivitis from concentrations below 10 ppm has been reported. Glacial acetic acid has caused permanent corneal opacification. Ingestion of 200 mL of an 80% solution of acetic acid caused repeated shock due to myocardial infarction and massive intestinal bleeding led to an or

Acetic acid is toxic due to its corrosive nature. In addition to causing skin burns and irritation to the mucous membranes, ingestion can result in severe damage to the digestive system and a potentially lethal change in the acidity of the blood. (L1885)

Chemical: Acetic acid

Commission Regulation (EU) No 231/2012 (amended)

Acetic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

2008/127, Reg. (EU) 2017/195, Reg. (EU) 2022/708, Reg. (EU) 2023/1446, Reg. (EU) No 540/2011, Reg. (EU) No 790/2013

Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15549

Acetic acid: Does not have an individual approval but may be used under an appropriate group standard

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl acetic acid, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including acetic acid, glacial, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Acetic acid used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: Acetic acid is included in topical otic drug products.

Residues of acetic acid are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals. Use: Catalyst. Limit: Not more than 0.5% of pesticide formulation.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. (a) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-contact surfaces in public eating places, dairy-processing equipment, and food-processing equipment and utensils. Acetic acid is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 290 ppm.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (b) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Dairy processing equipment, and food-processing equipment and utensils. Acetic acid is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 686 ppm.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Acetic acid is included on this list. When ready for use, the end-use concentration is not to exceed 686 ppm.

New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 044001; Type of Pesticide: biopesticide-herbicide; Use Site: non-food use (ornamental turf); Year: 1997.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Acetic acid is produced, as an intermediate or a final product, by process units covered under this subpart.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Acetic acid is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

G - Genito urinary system and sex hormones；G01 - Gynecological antiinfectives and antiseptics；G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids；G01AD - Organic acids；G01AD02 - Acetic acid

S - Sensory organs；S02 - Otologicals；S02A - Antiinfectives；S02AA - Antiinfectives；S02AA10 - Acetic acid

QS - Sensory organs；QS02 - Otologicals；QS02A - Antiinfectives；QS02AA - Antiinfectives；QS02AA10 - Acetic acid

QG - Genito urinary system and sex hormones；QG01 - Gynecological antiinfectives and antiseptics；QG01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids；QG01AD - Organic acids；QG01AD02 - Acetic acid

S02AA10

Although acetic acid has been shown to induce apoptosis in yeast, the exact apoptotic mechanisms remain unknown. Here, /the study examined/ the effects of acetic acid treatment on yeast cells by 2-DE, revealing alterations in the levels of proteins directly or indirectly linked with the target of rapamycin (TOR) pathway: amino-acid biosynthesis, transcription/translation machinery, carbohydrate metabolism, nucleotide biosynthesis, stress response, protein turnover and cell cycle. The increased levels of proteins involved in amino-acid biosynthesis presented a counteracting response to a severe intracellular amino-acid starvation induced by acetic acid. Deletion of GCN4 and GCN2 encoding key players of general amino-acid control (GAAC) system caused a higher resistance to acetic acid indicating an involvement of Gcn4p/Gcn2p in the apoptotic signaling. Involvement of the TOR pathway in acetic acid-induced apoptosis was also reflected by the higher survival rates associated to a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-negative phenotype and lower reactive oxygen species levels of Deltator1 cells. In addition, deletion mutants for several downstream mediators of the TOR pathway revealed that apoptotic signaling involves the phosphatases Pph21p and Pph22p but not Sit4p. Altogether, /these/ results indicate that GAAC and TOR pathways (Tor1p) are involved in the signaling of acetic acid-induced apoptosis.

Acetic acid was found to have actions on urinary bladder smooth muscle in /the/ routine ion channel screening assays. Numerous studies have examined the mechanisms of bladder irritation by acetic acid; however, the direct effect of acetic acid on ion channels in detrusor smooth muscle cells has not been evaluated. /The study/ used whole-cell patch-clamp techniques to examine the effect of acetic acid on large-conductance Ca2+-activated K+ channels (BKCa) from guinea pig detrusor smooth muscle cells and CHO cells expressing recombinant human BKCaalphabeta1 (CHO BKCaalphabeta1) and human BKCaalpha (CHO BKCaalpha). Acetic acid activated BKCa currents in a concentration-dependent (0.01% to 0.05% v/v) manner in all the cell systems studied. Acetic acid (0.05%) increased BKCa current at +30 mV by 2764 +/- 918% (n=8) in guinea pig detrusor smooth muscle cells. Acetic acid (0.03%) shifted the V1/2 of conductance-voltage curve by 64 +/- 14 (n=5), 128 +/- 14 (n=5), and 126 +/- 12 mV (n=4) in CHO BKCaalpha, CHO BKCaalphabeta1 and detrusor smooth muscle cells, respectively. This effect of acetic acid was found to be independent of pH and was also not produced by its salt form, sodium acetate. Automated patch-clamp experiments also showed similar activation of CHO BKCaalphabeta1 by acetic acid. In conclusion, acetic acid directly activates BKCa channels in detrusor smooth muscle cells. This novel study necessitates caution while interpreting the results from acetic acid bladder irritation model.

/It was/ previously shown that acetic acid activates a mitochondria-dependent death process in Saccharomyces cerevisiae and that the ADP/ATP carrier (AAC) is required for mitochondrial outer membrane permeabilization and cytochrome c release. Mitochondrial fragmentation and degradation have also been shown in response to this death stimulus. Herein, /the study/ show that autophagy is not active in cells undergoing acetic acid-induced apoptosis and is therefore not responsible for mitochondrial degradation. Furthermore, /the study/ found that the vacuolar protease Pep4p and the AAC proteins have a role in mitochondrial degradation using yeast genetic approaches. Depletion and overexpression of Pep4p, an orthologue of human cathepsin D, delays and enhances mitochondrial degradation respectively. Moreover, Pep4p is released from the vacuole into the cytosol in response to acetic acid treatment. AAC-deleted cells also show a decrease in mitochondrial degradation in response to acetic acid and are not defective in Pep4p release. Therefore, AAC proteins seem to affect mitochondrial degradation at a step subsequent to Pep4p release, possibly triggering degradation through their involvement in mitochondrial permeabilization. The finding that both mitochondrial AAC proteins and the vacuolar Pep4p interfere with mitochondrial degradation suggests a complex regulation and interplay between mitochondria and the vacuole in yeast programmed cell death.

Acetic acid ... is readily metabolized by most tissues and may give rise to the production of ketone bodies as intermediates. In vitro, acetate is incorporated into phospholipids, neutral lipids, steroids, sterols, and saturated and unsaturated fatty acids in a variety of human and animal tissue preparations. ...Metabolism of 14(C) acetate in mice results in radioactivity associated with the protein fractions of plasma and most major tissues.

In the body, acetic acid is partially converted into formic acid.

When dogs were administered large doses (1-2 g/kg ip or sc) of sodium acetate, only small amounts appeared in the urine, which is evidence of the rapid utilization of acetic acid.

Acetic Acid is a known human metabolite of acetaldehyde.

Acetic acid is is absorbed from the gastrointestinal tract and through the lungs. It is completely oxidized by the tissues, with metabolism involving the formation of ketone bodies. The products of acetic acid are used in the formation of glycogen, as intermediates of carbohydrates and fatty acid synthesis, and in cholesterol synthesis. In addition, acetic acid participates in the acetylation of amines and formation of proteins of plasma, liver, kidney, gut mucosa, muscle, and brain. (L1886)

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant &amp; Hackh&apos;s Chemical Dictionary, 5th ed, p301, p499)

Substances that inhibit the growth or reproduction of BACTERIA.

Acetic acid is absorbed from the GI tract and through the lung.

Kidney；Liver

Cytoplasm；Extracellular；Golgi apparatus；Mitochondria

Amino Sugar Metabolism；Aspartate Metabolism；Canavan Disease；Disulfiram Action Pathway；Ethanol Degradation；Fatty Acid Biosynthesis；G(M2)-Gangliosidosis: Variant B, Tay-sachs disease；Heroin Action Pathway；Heroin Metabolism Pathway；Hypoacetylaspartia；Total 19 pathways, visit the HMDB page for details

CIR ingredient: Acetic Acid

Used to manufacture acetic anhydride and other organic chemicals used in the plastic, pharmaceutical, dye, insecticide, textile, rubber, and photographic industries; [ACGIH] Used in photography (stop bath); [www.ci.tucson.az.us/arthazards/medium.html] Used as a wet etchant in semiconductor manufacturing at standard concentrations of 36% or 99.5%; [CSH, p. 46] Used in the bating and tanning stages of leather production; [PMID 21938525]

Semiconductor Manufacturing [Category: Industry]；Textiles (Fiber & Fabric Manufacturing) [Category: Industry]；Leather Tanning and Processing [Category: Industry]；Photographic Processing [Category: Other]；Textiles (Printing, Dyeing, or Finishing) [Category: Industry]；Burning Natural Polymers [Category: Burn]；Burning Synthetic Polymers [Category: Burn]

Sculpturing plastics [Category: Hobbies]；Textile arts [Category: Hobbies]；Smoking cigarettes [Category: Food & Drugs]；Applying metallic patinas [Category: Hobbies]；Burning biomass fuel for cooking and heating [Category: Environments]

For acetic acid (USEPA/OPP Pesticide Code: 044001) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Used as a laboratory reagent in chemical and biochemical analysis, in field testing of lead fumes, vinyl chloride determination, uric acid in urine, aniline vapors, and separation of gases. Used in miscellaneous applications for etching compounds for engraving; deliming agent during leather tanning, solvent for organic compounds, and oil well acidizer.

0.0001% CHLORIDE, 0.00005% LEAD, 0.00002% IRON; 0.015% SULFUR DIOXIDE; 0.001% SULFATE

Water is the chief impurity in acetic acid although other materials such as acetaldehyde, acetic anhydride, formic acid, biacetyl, methyl acetate, ethyl acetoacetate, iron and mercury are also sometimes found.

(1972) NEGLIGIBLE

(1975) 2.42X10+9 G

(1984) 9.17X10+9 g

(1972) 4.54X10+7 G

(1975) 2.72X10+8 G

2023: 7,000,000,000 - <8,500,000,000 lb；2022: 5,500,000,000 - <7,000,000,000 lb；2021: 7,000,000,000 - <8,500,000,000 lb；2020: 7,000,000,000 - <8,500,000,000 lb

(1972) 1.01X10+12 G

(1975) 9.98X10+11 G

(1984) 1.19X10+12 G /SYNTHETIC/

1990 1.71X10+12 G

For more U.S. Production (Complete) data for ACETIC ACID (14 total), please visit the HSDB record page.

Vinyl acetate monomer (VAM), 60%; acetic anhydride, including production of cellulose acetate, 10%; esters, 10%; CMT/PTA, 10%; miscellaneous, including textiles and chloroacetic acid, 10%.

Demand: 1994: 3.82 billion pounds; 1995: 3.9 billion pounds; 1999 /projected/: 4.2 billion pounds (Figures are for the US and include exports, which were 260 million pounds in 1993, but not imports, which were 25 million pounds.)

CHEMICAL PROFILE: Acetic acid. Demand: 1988: 3.36 billion lb; 1989: 3.45 billion lb; 1993 /projected/: 3.80 billion lb. (1988 figure includes imports of 193 million lb, much of which was brought in by Hoechst Celanese in response to the outage at Pampa; historically, imports are negligible. All figures include exports.)

Worldwide demand for acetic acid in 2011 was approximately 10.25X10+6 metric ton. Estimated demand for 2020 is approximately 15.94X10+6 metric ton.

For more Consumption Patterns (Complete) data for ACETIC ACID (6 total), please visit the HSDB record page.

Other；Solvent；pH regulating agent；Semiconductor and photovoltaic agent；Monomers；Processing aids not otherwise specified；Soil amendments (fertilizers)；Not Known or Reasonably Ascertainable；Diluent；Corrosion inhibitor；Cleaning agent；Fragrance；Laboratory chemicals；Anti-scaling agent；Intermediate

Plating agent；Chemical reaction regulator；pH regulating agent；Processing aids not otherwise specified；Monomers；Semiconductor and photovoltaic agent；Other；Lubricating agent；Solvent；Intermediates；Aerating and deaerating agents；Laboratory chemicals；Chelating agent；Drier；Etching agent；Processing aids, specific to petroleum production；Anti-scaling agent；Intermediate；Preservative；Corrosion inhibitor

The major routes for synthetic acetic acid include methanol carbonylation, acetaldehyde oxidation, butane/naphtha oxidation, and methyl acetate carbonylation. Comparatively small amounts are generated by butane liquid-phase oxidation, direct ethanol oxidation, and synthesis gas.

Obtained in the destructive distillation of wood; from acetylene and water, via acetaldehyde by oxidation with air.

Liquid- and vapor-phase oxidation of petroleum gases (with catalyst); ... oxidation of acetaldehyde; ... reaction of methanol and carbon monoxide (with catalyst; this is the most cost efficient method and has been in general use for some years); ... fermentative oxidation of ethanol.

Acetaldehyde (air oxidation): acetaldehyde + oxygen (Hoechst-Shawinigan process; coproduced with acetic anhydride): acetaldehyde (air oxidation; coproduced with peracetic acid): methanol + carbon monoxide (BASF/Monsanto carbonylation processes): methanol + carbon monoxide (BP acetyls process; coproduced with acetic anhydride): naphtha, heavy (liquid-phase oxidation; coproduced with acetone/methyl ethyl ketone/formic acid/propionic acid): n-butane (Celanese LPO process; coproduced with methanol/ethanol/acetone/methyl ethyl ketone/formic acid/propionic acid/n-butyric acid/methyl formate): acetic anhydride + cotton linters/bleached wood pulp (acetylation/partial hydrolysis; byproduct of cellulose acetate production)

Grades: USP /United States Pharmacopeia/ (glacial, 99.4 wt % and dilute, 36-37 wt %), CP /chemically pure: a grade designation signifying a minimum of impurities, but not 100% purity/; technical (80; 99.5%); commercial (6, 28, 30, 36, 56, 70, 80 and 99.5%); NF /national formulary/ (diluted; 6.0 g/100 mL).

Glacial acetic acid is considered to be 99.50 wt % or higher. A different grade has a minimum concentration of 99.70 wt %. Specialty users require water solutions of 86 and 36%. Such grades are prepared on special order. Only minor quantities of these grades are marketed, and their use is vanishing.

Vinegar... /is/ an aqueous solution containing about 4-12% acetic acid.

Ecosharp Weed & Grass Killer (Ecoval Corporation): Active ingredient: vinegar 25.0%.

For more Formulations/Preparations (Complete) data for ACETIC ACID (11 total), please visit the HSDB record page.

Information on 96 consumer products that contain Acetic acid in the following categories is provided:；• Auto Products；• Commercial / Institutional；• Home Maintenance；• Inside the Home；• Landscaping/Yard；• Personal Care；• Pesticides；• Pet Care

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Food additives

Fragrance Ingredients

Flavouring Agent -> -> JECFA Functional Classes；FLAVOURING_AGENTFood Additives -> ACIDACIDITY_REGULATORPRESERVATIVE -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index