uspto-grants-2016_09
uspto-grants-2016_09 · 10.6084/m9.figshare.5104873.v1 · US09440976B2
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COMPUTED
PROPERTIES
Odorless
3.98
3.89 @25 °C
White crystals or crystalline powder
Colorless monoclinic crystals
4.74 g/100 cc water @ 0 °C; 32.3 g/100 cc @ 100 °C; insol in alc, nitric acid; sol in potassium iodide
Sol in dil sulfuric acid
9.16 g/100 g H20 at 25 °C
When heated to decomposition it emits very toxic fumes.
560 °C
560 °C
White crystals or crystalline powder. [HSDB]
Partial decomp @ 560 °C
DECOMP @ GREATER THAN 100 °C
GHS
Danger
H272 (85.3%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids];H302 (58.2%): Harmful if swallowed [Warning Acute toxicity, oral];H315 (59.6%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (66.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (59.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P210, P220, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 443 reports by companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
HAZARDS
Chemical: Iodic acid (HIO3), potassium salt
Status: Active Update: 01-07-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/13616
Iodic acid, potassium salt: Does not have an individual approval but may be used under an appropriate group standard
IMAP assessments - Iodic acid and selected salts: Human health tier II assessment
...DANGEROUS BECAUSE THEY ARE STRONG OXIDIZERS. IN CONTACT WITH FLAMMABLE OR EVEN COMBUSTIBLE MATERIALS THEY CAN START FIRES. /IODATES/
Causes gastrointestinal tract, liver, and kidney injury in high-dose animal experiments; [HSDB]
Substance added directly to human food affirmed as generally recognized as safe (GRAS).
REVIEW OF THE HEALTH ASPECTS OF POTASSIUM IODIDE, POTASSIUM IODATE, & CALCIUM IODATE AS FOOD INGREDIENTS.[LIFE SCIENCES RESEARCH OFFICE/FEDERATION OF AMERICAN SOCIETIES FOR EXPTL BIOLOGY; EVALUATION OF THE HEALTH ASPECTS OF POTASSIUM IODIDE, POTASSIUM IODATE, & CALCIUM IODATE AS FOOD INGREDIENTS; USNTIS PB REPORT PB-254 533: 22 PP (1975)]
Ox. Sol. 2 (85.3%);Acute Tox. 4 (58.2%);Skin Irrit. 2 (59.6%);Eye Irrit. 2 (66.8%);STOT SE 3 (59.4%)
Acute toxicity (ingestion) - category 4;Specific target organ toxicity (single exposure) - category 2
Acute toxicity (Oral) - Category 4
CAN REACT VIGOROUSLY WITH REDUCING MATERIALS
Potentially explosive reaction with charcoal + ozone; metals; arsenic; carbon; phosphorus; sulfur; alkali metal hydrides; alkaline earth metal hydrides; antimony sulfide; arsenic sulfide; copper sulfide; tin sulfide; metal cyanides; metal thiocyanates; manganese dioxide. Violent reaction with organic matter.
SAFETY
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
3.6 [mg/m3]
40 [mg/m3]
240 [mg/m3]
TOXICITY
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
NO HUMAN INGESTION OF IODATE SALTS CAN BE CITED. /IODATE SALTS/
...IN FASTING DOG...0.2-0.25 G/KG...USUALLY CAUSE/S/ EMESIS, BUT IF THIS IS PREVENTED SIGNS OF ANOREXIA AND PROSTRATION PRECEDE DEATH. NECROTIC LESIONS OF THE LIVER, KIDNEYS AND GASTRIC AND INTESTINAL MUCOSA...
POTASSIUM & SODIUM IODATE HAVE ABOUT THE SAME LD50 & PRODUCE DEATH IN ACUTE RENAL FAILURE /IN MICE/...SOMETIMES HEMOGLOBINURIA PRECEDED RENAL SHUTDOWN.
POTASSIUM IODATE INDUCED STERILITY IN COPTA MITE (T PUTRESCENTIAE) WHEN GIVEN IN DIET @ 0.25-1.0% CONCN FOR 1-2 WK. FEMALES WERE MORE SUSCEPTIBLE THAN MALES. EGG FORMATION WAS DETRIMENTALLY AFFECTED.
POTASSIUM IODATE INDUCED DEFORMED SPIRACLES IN PUPAE WHEN FED TO SILKWORM LARVAE @ 100 PPM IODINE.
LD50 Mouse ip 136 mg/kg
REGULATORY
Chemical: Iodic acid (HIO3), potassium salt
Status: Active Update: 01-07-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/13616
Iodic acid, potassium salt: Does not have an individual approval but may be used under an appropriate group standard
Substance added directly to human food affirmed as generally recognized as safe (GRAS).
PHARMACOLOGY
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
USES
Used as a reagent to test for zinc and arsenic, a photographic emulsion, a feed additive, a dietary supplement, and in spectroscopy, infrared transmission, and scintillation; [Hawley] Classification code: Anti-infective agents; antifungal agents; [ChemIDplus]
Photographic Processing [Category: Other];Farming (Feed Additives) [Category: Industry]
MEDICATION (VET)
Medication
Oxidizing agent in volumetric chemical analysis
REAGENT IN MERCURY REDN METHOD OF PYRETHRIN ANALYSIS
Prepared by dissolving iodine in a caustic alkali solution and recovering the iodate by filtration.
Prepared by oxidation of iodine to iodic acid, followed by neutralization with an oxide or hydroxide; or by electrolytic oxidation of an iodide solution.
Grades: ...CP; FCC; Technical
/Available as/ techincal, FCC food grades; 99.9% purity grade; ACS reagent grade
Food Additives -> FLOUR_TREATMENT_AGENT -> JECFA Functional Classes
Iodic acid (HIO3), potassium salt (1:1): ACTIVE
RECOMMENDED BY WORLD HEALTH ORGANIZATION AS AN ADDITIVE TO TABLE SALT TO PREVENT GOITER /IODATES/.
Iodates are precipitated when solutions of metal salts react with alkali-metal iodates.
Formed when potassium iodide is fused with potassium chlorate, bromate, or perchlorate.
ALIASES
REACTIONS
uspto-grants-2016_09
uspto-grants-2016_09 · 10.6084/m9.figshare.5104873.v1 · US09440976B2
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