uspto-grants-1988_02 · 10.6084/m9.figshare.5104873.v1 · US04723007
查看IDENTITY
结构与身份
- 标准SMILES
- c1ccc(N2CCNCC2)cc1
- InChIKey
- YZTJYBJCZXZGCT-UHFFFAOYSA-N
- 分子式
- C10H14N2
- 平均分子量
- 162.23 g/mol
- 单同位素质量
- 162.11569846
COMPUTED
结构计算性质
- XLogP
- 1.1
- 极性表面积
- 15.3 Ų
- 氢键供体
- 1
- 氢键受体
- 2
- 可旋转键
- 1
- 重原子
- 12
- 形式电荷
- 0
- 复杂度
- 124
PROPERTIES
实验与物化性质
Dissociation Constants
9
GHS
GHS分类
GHS Classification
Danger
H301 (96.9%): Toxic if swallowed [Danger Acute toxicity, oral];H310 (36.9%): Fatal in contact with skin [Danger Acute toxicity, dermal];H311 (61.5%): Toxic in contact with skin [Danger Acute toxicity, dermal];H314 (98.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
P260, P262, P264, P270, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 65 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
HAZARDS
危害信息
Regulatory Information
Status: Active Update: 09-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/21606
Piperazine, 1-phenyl-, dihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Phenylpiperazine: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories
Acute Tox. 3 (96.9%);Acute Tox. 2 (36.9%);Acute Tox. 3 (61.5%);Skin Corr. 1B (98.5%)
REGULATORY
法规信息
Regulatory Information
Status: Active Update: 09-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/21606
Piperazine, 1-phenyl-, dihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Phenylpiperazine: Does not have an individual approval but may be used under an appropriate group standard
PHARMACOLOGY
药理信息
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).
USES
用途与制造
General Manufacturing Information
Piperazine, 1-phenyl-: INACTIVE
ALIASES
名称与别名
REACTIONS
参与反应
uspto-grants-1988_02 · 10.6084/m9.figshare.5104873.v1 · US04723003
查看uspto-grants-1993_09 · 10.6084/m9.figshare.5104873.v1 · US05245034
查看uspto-grants-1993_09 · 10.6084/m9.figshare.5104873.v1 · US05245034
查看uspto-grants-1993_09 · 10.6084/m9.figshare.5104873.v1 · US05245034
查看uspto-grants-2006_08 · 10.6084/m9.figshare.5104873.v1 · US07087644B1
查看uspto-grants-2006_08 · 10.6084/m9.figshare.5104873.v1 · US07091199B1
查看uspto-grants-2006_08 · 10.6084/m9.figshare.5104873.v1 · US07091199B1
查看