uspto-grants-2013_09 · 10.6084/m9.figshare.5104873.v1 · US08524704B2
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IDENTITY
结构与身份
- 标准SMILES
- CCC(N)Cc1c[nH]c2ccccc12
- InChIKey
- ZXUMUPVQYAFTLF-UHFFFAOYSA-N
- 分子式
- C12H16N2
- 平均分子量
- 188.27 g/mol
- 单同位素质量
- 188.13134852
COMPUTED
结构计算性质
- XLogP
- 2.5
- 极性表面积
- 41.8 Ų
- 氢键供体
- 2
- 氢键受体
- 1
- 可旋转键
- 3
- 重原子
- 14
- 形式电荷
- 0
- 复杂度
- 181
PROPERTIES
实验与物化性质
LogS
-2.57
Solubility
510
Melting Point
221
Kovats Retention Index
1848
HAZARDS
危害信息
Regulatory Information
DEA schedule I controlled substance
REGULATORY
法规信息
Regulatory Information
DEA schedule I controlled substance
PHARMACOLOGY
药理信息
Pharmacodynamics
αET is a stimulant and psychedelic with MDMA like physiological effects. Like MDMA, increases in locomotor activity and mood elevation can be seen post administration. [2]
Mechanism of Action
The mechanism of action responsible for its antidepressant activity was believed to lie in its ability to inhibit monoamine oxidase, while its stimulant activity on the central nervous system appeared to result from its structural similarity to indole-based psychedelics. [5] Research discovered αET to be both a monoamine oxidase inhibitor and a potent monoamine releasing agent capable of serotonergic neurotoxicity. [3] The ability to release serotonin was linked to αET's MDMA like properties. [2] αET has been shown to release serotonin pre-synaptically, as well as lesser amounts of norepinephrine and dopamine.
ALIASES
名称与别名
ETRYPTAMINEalpha-Ethyltryptamine3-(2-Aminobutyl)indole2235-90-73-IndolylbutylamineEtriptaminaMonaseRo 3-1932Etryptaminum1H-Indole-3-ethanamine, alpha-ethyl-alphaETDTXSID1046764NSC-88061GR181O3R32DTXCID9026764NSC880612-ethyltryptamine3-(2-aminobutylindole)RefChem:1393041-(1H-indol-3-yl)butan-2-amine
REACTIONS
