HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Mangandi(acetat)
MANGANESE ACETATE · MANGANESE(II) ACETATE · octanmanganaty · manganousacetate · diacetylmanganese · anese(II) acetate · manganesediacetate · manganese(2+)acetate
Identifikatoren & physikalische Daten
| CAS No. | 638-38-0 |
|---|---|
| Summenformel | C4H6MnO4 |
| Durchschnittliche Molmasse | 173,03 g/mol |
| Monoisotopische Masse | 172,96465377 g/mol |
| SMILES | CC(=O)[O-].CC(=O)[O-].[Mn+2] |
| InChIKey | UOGMEBQRZBEZQT-UHFFFAOYSA-L |
| PubChem CID | 12525 |
| EC No. | 211-334-3 |
| DTXSID | DTXSID5027279 |
| Lokaler Name | Mangandi(acetat) |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 80,3 |
|---|---|
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 9 |
| Formalladung | 0 |
| Komplexität | 25,5 |
| Stoffklassen | Metals -> Organic Acids, Metal Salts |
| Dichte | 1.74Red monoclinic crystalsMP 80 °Cdensity 1.59 g/cu cmsoluble in water and ethanol. /Tetrahydrate/1.59 @25 °C1.589 |
| Color/Form | BROWN CRYSTALS |
| Löslichkeit | SOL IN ALCOHOLSoluble in water, methanol and acetic acid. |
| Schmelzpunkt | 175 °C180°C |
| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
| Physical Description | Large CrystalsDry PowderLiquidBrown crystals[HSDB] |
| Other Experimental Properties | Cinnamon brown crystal soliddecomposes in water. /Dihydrate/Pink crystalssoluble in methanoldehydrates between 80-130 °Cdecomposes at 350 °C to manganese(III) oxide. /Tetrahydrate/ |
| Dampfdruck | 13hPa at 25℃ |
| Lagerbedingungen | Store below +30°C. |
| Aggregatzustand | Powder |
| Farbe | Grayish-beige to light brown |
| Merck | 13,5746 |
| InChI | InChI=1S/2C2H4O2.Mn/c2*1-2(3)4/h2*1H3,(H,3,4)/q+2/p-2 |
| InChIKey | NKKRYPIWDQMINN-UHFFFAOYSA-M |
| SMILES | C(=O)(C)O[Mn]OC(=O)C |
| CAS Datenbank | 638-38-0(CAS DataBase Reference) |
| EPA chemische Informationen | Acetic acid, manganese(2+) salt (638-38-0) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 13.6% (99 of 729) of reports.WarningH315 (86.1%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 729 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Not Classified |
|---|---|
| Regulatorische Informationen | Chemical: Acetic acid, manganese(2+) saltAcetic acid, manganese(2+) salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, manganese(2+) salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 06-05-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13305Acetic acid, manganese(2+) salt: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - Soluble manganese compounds: Human health tier II assessment |
| Gefahrenübersicht | See Manganese and linked occupational diseases. |
| FDA-Anforderungen | Manganese acetate is an indirect food additive for use only as a component of adhesives.Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added at levels consistent with good feeding practice. Element: ManganeseSource compound: manganese acetate. (All substances listed may be in anhydrous or hydrated form.) |
| OSHA Standards | Permissible Exposure Limit: Table Z-1 Ceiling value: 5 mg/cu m. /Manganese cmpd (as Mn)/ |
| Luftstandards | Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Manganous acetate is included on this list.... Substances for which a Federal Register notice has been published that included consideration of the serious health effects, including cancer, form ambient air exposure to the substance. Manganese (50 FR 32627Aug. 13, 1985) is included on this list. /Manganese/ |
| NIOSH Recommendations | Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Manganese compounds and fume (as Mn)/Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 3 mg/cu m. /Manganese compounds and fume (as Mn)/ |
| Hazard Classes and Categories | Skin Irrit. 2 (86.1%)Acute toxicity - category 4Acute toxicity (Oral) - Category 4 |
| State Drinking Water Standards | (IL) ILLINOIS 150 ug/l /Manganese/(NC) NORTH CAROLINA 50 ug/l /Manganese/(NY) NEW YORK 300 ug/l /Manganese/ |
| Landesrichtlinien für Trinkwasser | (CT) CONNECTICUT 500 ug/l /Manganese/(ME) MAINE 200 ug/l /Manganese/(MN) MINNESOTA 300 ug/L /Manganese/ |
| Bundesrichtlinien für Trinkwasser | EPA 50 ug/l /Manganese/ |
| Expositionsschutz und Persönliche Schutzausrüstung | 0.2 [mg/m3], as Mn (inhalable fraction), 0.02 mg/m3, as Mn (respirable fraction)[German Research Foundation (DFG)] |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Preventive Measures | SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. |
| Minimum Risk Level | Chronic Inhalation: 0.0003 mg/m3 (L134) |
| Threshold Limit Values (TLV) | 0.02 [mg/m3], as Mn (respirable fraction), 0.1 mg/m3, as Mn (inhalable fraction) |
| Protective Action Criteria (PAC) | 9.4 [mg/m3]16 [mg/m3]96 [mg/m3] |
| Immediately Dangerous to Life or Health (IDLH) | 500 mg/cu m /Manganese compounds and fume (as Mn)/ |
| Gesundheitliche Auswirkungen | Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as |
| Unerwünschte Wirkungen | Neurotoxin - Parkinsonism |
| Expositionspfade | Oral (L228)inhalation (L228) |
| Toxizitätsübersicht | Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant enzyme manganese superoxide dismutase. The neurotoxicity of Mn(II) has also been linked to its ability to substitute for Ca(II) under physiological conditions. It can enter mitochondria via the calcium uniporter and inhibit mitochondrial oxidative phosphorylation. It may also inhibit the efflux of Ca(II), which can result in a loss of mitochondrial membrane integrity. Mn(II) has been shown to inhibit mitochondrial aconitase activity to a significant level, altering amino acid metabolism and cellular iron homeostasis. (L228) |
| Signs and Symptoms | Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Non-Human Toxicity Excerpts | This work has identified the relative toxicity of four forms of manganese, using biogenic amine levels, tissue retention, weight gain, & activity scores as criteria. Male mice were chronically treated with four forms of manganese administered orally, mixed with the diet, for 12 months. The food intake for the control mice & the mice exposed to manganese was similar, but the manganese treatment reduced normal weight gain in the mice. The Mn levels were higher in some parts of brain after feeding insoluble salts than after the soluble salts. The concn of manganese was significantly increased in the liver & spleen of the manganese carbonate-exposed group, compared with the concn in the control group. Manganese dioxide feeding lowered dopamine & increased homovanilic acid. Since manganese dioxide is a powerful oxidizing agent in organic chemistry, it possibly enhanced the oxidative metabolite of dopamine. Accumulation of manganese in the brain correlated with reduced hypothalamic dopamine levels in the manganese acetate-exposed group& the amount of manganese accumulated correlated with the intensity of suppression of motor activity. These findings indicate that manganese dioxide is more toxic than divalent manganese. Of the divalent manganese cmpds, manganese acetate seemed to have the greatest toxic effect. |
| Antidote and Emergency Treatment | Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Manganese and related compounds/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Manganese and related compounds/ |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 2915 29 00 |
| RTECS-Nr. | AI5770000 |
| R-Sätze (R) | 20/21/22-36/37/38-40 |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 26-27-36/37/39 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 638-38-0(Hazardous Substances Data) |
| Gefahrenklasse | Aquatic Chronic 3STOT RE 2 Inhalation |
Anwendungen & Verwendung
Beschreibung
Manganese (II) acetate is the chemical compound with the formula Mn(CH3COO)2. It is used as a desiccant, a catalyst, and as fertilizer.
Verwenden
Manganese(II) acetate is used as a dye mordant and varnish drier. It is also used in fertilizers, food packaging and feed additives. Further, it serves as a desiccant, catalyst, intermediate and ion exchange agent.