| GHS-Einstufung | DangerH271 (26.7%): May cause fire or explosionstrong Oxidizer [Danger Oxidizing liquidsOxidizing solids]P203, P210, P220, P233, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P283, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P306+P360, P316, P317, P318, P319, P320, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P363, P370+P378, P371+P380+P375, P391, P403, P403+P233, P405, P420, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 101 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H301: Toxic if swallowed [Danger Acute toxicity, oral] |
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| Regulatorische Informationen | Chemical: Chromic acid (H2CrO4)Chromic acid (H2CrO4) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Chromic acid (H2CrO4) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)R - indicates a substance that is the subject of a TSCA section 6 risk management rule.Substance: Chromic acidChromic (VI) acid: HSNO Approval: HSR003152 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| Weitere Sicherheitsinformationen | IMAP assessments - Chromium trioxide and related compounds: Human health tier II assessment |
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| Brandgefahren | · Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. |
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| Gesundheitsgefahren | · TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. |
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| Gefahrenübersicht | Classified as a water-soluble, hexavalent chromium compound[ACGIH] Chronic exposure to hexavalent chromium may produce evidence of kidney and liver injury. [ATSDR Case Studies # 4] Can cause second and third degree burns on short contact[CHRIS] Highly corrosive to skin[Quick CPC] Occupational asthma documented in a cement floor worker, plater, and other workers exposed to chromate salt[Malo] Epidemiological studies of chromate production workers showed increased lung cancer. [IARC] See Chromium and linked occupational diseases. |
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| DOT-Nummer und Handbuch | 1755 154 |
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| RCRA-Anforderungen | D007A solid waste containing chromium may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Chromium/ |
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| FIFRA-Anforderungen | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Chromic acid is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0132Pesticide type: fungicide (wood perserative)Registration Standard Date: 06/01/88, 09/10/86Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): Chromic acidData Call-in (DCI) Date(s): 01/31/94AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner. |
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| OSHA Standards | Permissible Exposure Limit: Table Z-2 Acceptable Ceiling Concentration: 1 mg/10 cu m. /Chromic acid and chromates/ |
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| Luftstandards | Chromium has been designated as a hazardous air pollutant under section 112 of the Clean Air Act. /Chromium/ |
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| DOT Emergency Guidelines | /GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXICinhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Chromic acid, solution//GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. /Chromic acid, solution//GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Chromic acid, solution//GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLYit is not effective in spill situations where direct contact with the substance is possible. /Chromic acid, solution/For more DOT Emergency Guidelines (Complete) data for CHROMIC ACID (8 total), please visit the HSDB record page. |
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| EPA Hazardous Waste Number | D007A waste containing chromium may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Chromium/ |
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| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
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| Erste Hilfe | General First Aid: |
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| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA).TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016]. |
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| Brandbekämpfungsverfahren | If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Cool all affected contrainers with flooding quantities of water. Apply water from as far a distrance as possible. /Chromic acid solution/ |
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| Lagerbedingungen | PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ |
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| Reinigungsverfahren | PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with agricultural lime (CaO), crushed limestone (CaCO3) or sodium bicarbonate (NaHCO3).Environmental considerations: Water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH=7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Chromic acid solution/Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment. /Chromic acid solution/ |
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| Entsorgungsverfahren | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D007, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.The following wastewater treatment technologies have been investigated for chromic acid: Concentration process: Reverse Osmosis.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/For more Disposal Methods (Complete) data for CHROMIC ACID (8 total), please visit the HSDB record page. |
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| Preventive Measures | If employees' clothing may have become contaminated with solids or liquids containing chromic acid or chromates, employees should change into uncontaminated clothing before leaving the work premises.Clothing contaminated with chromic acid or chromates should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of substance from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the chromic acid or chromates, the person performing the operation should be informed of chromic acid or chromates hazardous properties.Where there is any possibility of exposure of an employee's body to solids or liquids containing chromic acid or chromates, facilities for quick drenching of the body should be provided within the immediate work area for emergency use.Non-impervious clothing which becomes contaminated with chromic acid or chromates should be removed immediately and not reworn until the substance is removed from the clothing.For more Preventive Measures (Complete) data for CHROMIC ACID (23 total), please visit the HSDB record page. |
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| Isolation and Evacuation | Immediate precautionary measure |
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| Minimum Risk Level | Intermediate Oral: 0.005 mg/kg/day (L134)
Chronic Oral: 0.001 mg/kg/day (L134) |
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| Threshold Limit Values (TLV) | 0.0002 [mg/m3], as Cr(VI), inhalable particulate matter0.0005 [mg/m3], as Cr(VI), inhalable particulate matter8 hr Time Weighted Avg (TWA): 0.05 mg/cu m /Chromium and inorganic compounds, as Crwater-soluble Cr VI compounds/A1: Confirmed human carcinogen. /Chromium and inorganic compounds, as CrBiological Exposure Index (BEI): Determinant: total chromium in urineSampling Time: end of shift at end of workweekBEI: 25 ug/L. /Chromium (VI), Water-soluble fume/Sampling Time: increase during shiftBEI: 10 ug/L. /Chromium (VI), Water-soluble fume/ |
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| Personal Protective Equipment (PPE) | Employees should be provided with and required to use impervious clothing, gloves, face shields (eight-inch minimum), and other appropriate protective clothing necessary to prevent any possiblity of skin contact with solids or liquids containing chromic acid or chromates.Wear appropriate personal protective clothing to prevent skin contact. /Chromic acid and chromates/Wear appropriate eye protection to prevent eye contact. /Chromic acid and chromates/Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substancesthis is irrespective of the recommendation involving the wearing of eye protection. /Chromic acid and chromates/For more Personal Protective Equipment (PPE) (Complete) data for CHROMIC ACID (10 total), please visit the HSDB record page. |
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| Treatment | The mainstay of treatment of any acid burn is copious irrigation with large amounts of tap water. To be most effective, treatment should be started immediately after exposure, preferably before arrival in the emergency department. Remove any contaminated clothing. Do not attempt to neutralize the burn with weak reciprocal chemicals (i.e. alkali for acid burns), because the heat generated from the chemical reaction may cause severe thermal injury. |
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| Gesundheitliche Auswirkungen | Skin contact with chromic acid can cause redness, pain, and severe skin burns. Chromic acid may cause severe burns to the eye and permanent eye damage. Severe and rapid corrosive burns of the mouth, gullet and gastrointestinal tract will result if chromic acid is swallowed. Symptoms include burning, choking, nausea, vomiting and severe pain. Chronic exposure to low levels of chromic acid can lead to chronic exposure to hexavalent chromium. Hexavalent chromium is a known carcinogen. Chronic inhalation especially has been linked to lung cancer. Hexavalent chromium is also known to cause reproductive and developmental defects. (A12) |
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| Ökotoxizitätswerte | LC50Species: Colinus virginianus (Northern Bobwhite Quail) diet (chemical incorporated into food) >5100 ppm for 8 daysLD50Species: Colinus virginianus (Northern Bobwhite Quail) age 38 wkoral via capsule 164 mg/kg (95% confidence interval: 125-250 mg/kg)Species: Anas platyrhynchos (Mallard Duck) age 10 daysdiet (chemical incorporated into food) >5100 ppm for 8 daysEC50Species: Daphnia magna (Water Flea) age <24 hrConditions: freshwater, staticConcentration: 760 ug/L for 48 hr (95% confidence interval: 680-900 ug/L)Effect: intoxication, immobilization /57% purity/For more Ecotoxicity Values (Complete) data for CHROMIC ACID (7 total), please visit the HSDB record page. |
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| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
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| Expositionspfade | Oral (L16)inhalation (L16)dermal (L16) |
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| Toxizitätsübersicht | IDENTIFICATION AND USE: Chromic acid forms dark purplish-red crystals. It is used as photographic chemicalaluminum anodizing reagentchrome electroplating/zinc colorless conversion coatings reagentside-chain oxidation reagent, and wood preservative. HUMAN EXPOSURE AND TOXICITY: Repeated or prolonged exposure to chromic acid or chromate dust or mist may cause an ulceration and perforation of the nasal septum. Respiratory irritation may occur with symptoms resembling asthma. Liver damage with yellow jaundice has been reported. Prolonged or repeated exposure of the skin may cause a skin rash. Allergic skin rash may also occur. Contact causes severe eye injury characterized by infiltration, vascularization, and opacification of the cornea. Full-thickness skin burns covering as little as 1% of the body surface area may lead to irreversible acute tubular necrosis secondary to acute chromium intoxication. The mortality rate is high if the burned area exceeds approximately 10% of the body surface. The correlation with duration of chrome bath work associated with exposure to chromium acid was positive only for cancers of the lung and bronchus in male workers. It was experimentally and epidemiologically confirmed that hexavalent chromium compounds act as carcinogens and cause specific biological effects on the respiratory system. These characteristics of hexavalent compounds might be attributable to the strong oxidizing potency and/or high permeability through the cell membrane. Furthermore, hexavalent compounds might be entirely different in biological action from trivalent compounds which are chemically most stable. ANIMAL STUDIES: There is limited evidence in experimental animals for the carcinogenicity of chromic acid. There was an increased incidence in abnormalities (cleft palate, cleft sternum, perforated sternum) in developmental studies in mice. In CHO cells, there was a significant increase in SCE with CrVI compounds. In the Ames test there was a dose-response for increase in revertant colonies for all CrVI compounds at 10-200 ug/plate with TA1537, TA98 and TA100. Addition of S9 did not affect mutation incidence. In other studies, when tested in Salmonella typhimurium strains TA1537, TA1538, TA98 and TA100 the S9 mix decreased the mutagenicity of CrVI compounds.Chromic acid is highly corrosive and strongly oxidative. Many strong acids cause tissue burns through the denaturation of proteins and partial hydrolysis of proteins. Most proteins denature at pH values of less than 3-4. The large-scale denaturation of proteins, de-esterification of lipids and subsequent desiccation of tissues leads to chemical burns. . Symptoms include itching, bleaching or darkening of skin or tissues, blistering and burning sensations. Chromic acid also denatures proteins through inserting oxygen atoms into protein side chains. Chromic acid is also a source of chromium and especially hexavalent chromium. Hexavalent chromium compounds (including chromium trioxide, chromic acids, chromates, chlorochromates) are toxic and carcinogenic. For this reason, chromic acid oxidation is not used on an industrial scale except in the aerospace industry. Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produced during reoxidation of pentavalent chromium by hydrogen peroxide molecules present in the cell. Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, chromium-DNA adducts, chromosomal aberrations and alterations in cellular signaling pathways. It has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. It can also cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (A12, L16, A34, A35, A36) |
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| Signs and Symptoms | Skin contact can cause redness, pain, and severe skin burns. Chromic acid may cause severe burns to the eye and permanent eye damage. Severe and rapid corrosive burns of the mouth, gullet and gastrointestinal tract will result if chromic acid is swallowed. Symptoms include burning, choking, nausea, vomiting and severe pain. |
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| Medical Surveillance | PRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/ |
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| TSCA Test Submissions | Chromic (VI) Acid (CAS #7738-94-5) was tested for carcinogenicity in Porton Wistar rats (52 females/48 males) exposed for up to 2 years to 2 mg of the test compound in stainless steel mesh pellets surgically implanted in the left inferior bronchiolus. Control rats (25-50/sex/treatment group) received a similar treatment with 2 mg of cholesterol (negative control) or 2 mg of 20-methylcholanthrene (positive control) or calcium chromate (positive control). Treatment with the test compound had no adverse effects with respect to mortality rate, body weights, or non-lung tumors. There were two occurrences of bronchial carcinomas out of 100 lungs examined and was considered not significant when analyzed by statistical methods based on the Null Hypothesis. Both groups of positive control rats had an increased incidence (25-46%) of bronchial carcinomas, as compared to the negative control group (0%).Chromic (VI) Acid (CAS #7738) was tested for carcinogenicity in Porton Wistar rats (52 females/48 males) exposed for up to 2 years to 2 mg of the test compound in stainless steel mesh pellets surgically implanted in the left inferior bronchiolus. Control rats (25-50/sex/treatment group) received a similar treatment with 2 mg of cholesterol (negative control) or 2 mg of 20-methylcholanthrene (positive control) or calcium chromate (positive control). Treatment with the test compound had no adverse effects with respect to mortality rate, body weights, or non-lung tumors. There were two occurrences of bronchial carcinomas out of 100 lungs examined and was considered not significant when analyzed by statistical methods based on the Null Hypothesis. Both groups of positive control rats had an increased incidence (25-46%) of bronchial carcinomas, as compared to the negative control group (0%). |
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| Human Toxicity Excerpts | /SIGNS AND SYMPTOMS/ Repeated or prolonged exposure to chromic acid or chromate dust or mist may cause an ulceration & perforation of the nasal septum. Respiratory irritation may occur with symptoms resembling asthma. Liver damage with yellow jaundice has been reported. Prolonged or repeated exposure of the skin may cause a skin rash. Allergic skin rash may also occur./SIGNS AND SYMPTOMS/ Contact causes severe injury characterized by infiltration, vascularization, & opacification of the cornea. Chronic exposure to fine droplets in the air from electroplating baths or transfer to the eyes on the fingers causes chronic conjunctival inflammation & in rare instances a brown band in the superficial layers of the cornea./SIGNS AND SYMPTOMS/ Splash contact of concentrated strong acids, such as ... chromic acid ... can prove as severely & devastatingly injurious to the eye as splashes of strong alkalies./SIGNS AND SYMPTOMS/ Symptomatology (after ingestion or skin contact): 4) Circulatory collapse with clammy skin, weak and rapid pulse, shallow respirations, and scanty urine. Circulatory shock is often the immediate cause of death. 5) Asphyxial death due to glottic edema. 6) Late esophageal, gastric and pyloric strictures and stenoses, which may require major surgical repair, should be anticipated. Signs of obstruction commonly appear within a few weeks but may be delayed for months and even years. Permanent scars may also appear in the cornea, skin and oropharynx. 7) Uncorrected circulatory collapse of several hours' duration may lead to renal failure and ischemic lesions in the liver and heart.For more Human Toxicity Excerpts (Complete) data for CHROMIC ACID (12 total), please visit the HSDB record page. |
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| Carcinogen Classification | 1, carcinogenic to humans. (L135) |
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| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ The effects of the chromic acid mist used in electroplating on the respiratory system of C57BL mice (femalen = 43) were examined histopathologically after exposure for 12 mo to the mist (1.81 mg chromium/cu m-120 min, twice a week). Among the 23 mice sacrificed at 12 mo after the first exposure, three cases of perforation in the nasal septum, a case of proliferative change of the tracheal epithelium, nine cases of emphysema and four of adenomatous metaplasia of the lungs were observed on autopsy. Among the 20 mice which were sacrificed six months after the last exposure, the same changes as the 12 mo exposure group were also observed in the nasal septum, trachea and lungs, but papillomas observed in the nasal epithelia of six mice and adenoma in the lung of a mouse were new findings not seen in the 12 mo exposure group. These results suggest that, in view of the low incidence of spontaneous lung tumor in C57BL mice, inhalation of chromic acid mist in electroplating might be a risk factor of lung cancer. Additionally, the occurrence of papillomas in the nasal epithelium demonstrates the need of directing attention to the possible development of cancer of the upper respiratory tract in chromium electroplating workers. Upon completion of our five reports on the effects of chromium compounds on the respiratory system, a recapitulation of our experimental studies was made and compared with the findings of a number of reports on chromium. It was experimentally and epidemiologically confirmed that hexavalent chromium compounds act as carcinogens and cause specific biological effects on the respiratory system. These characteristics of hexavalent compounds might be attributable to the strong oxidizing potency and/or high permeability through the cell membrane. Furthermore, hexavalent compounds might be entirely different in biological action from trivalent compounds which are chemically most stable./LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Chromic Acid Solution -60% (purity = 55.05%) was administered by gavage to artificially inseminated female New Zealand white rabbits (16/dose) at 0 (deionized water), 0.1, 0.5, 2.0 and 5.0 mg/kg/day during gestation days 7 through 19. Maternal NOEL = 0.5 mg/kg (Mortality for does was 6.25 and 31% at 2 and 5 mg/kg/day, respectively. Abortion occurred in 8.33 and 33.3% at 2 and 5 mg/kg/day. The incidence of total litter resorptions (7-46%) was detected mainly as implantation loss. Food consumption was statistically significantly lower at 5 mg/kg/day but at 2 mg/kg it was decreased 12-21%. Clinical observations were increased at > or =2 mg/kg.) Developmental NOEL = 5.0 mg/kg (There were no treatment-related effects at any dose)./LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Chromic Acid Solution -60% (purity = 55.05%) administered by gavage to mated CD-1 mice (25/dose) at 0 (deionized water), 5, 20, 60 or 120 mg/kg/day during gestation days 6 through 15. Maternal NOEL = 5 mg/kg/day (Possible adverse effect: 1 dam at 120 mg/kg had total litter resorption. Food consumption was reduced up to 12, 19 and 28% for 20, 60 and 120 mg/kg/day, respectively. The death of a high dose dam was considered treatment-related.) Developmental NOEL = 20 mg/kg (There was an increased incidence in abnormalities (cleft palate, cleft sternum, perforated sternum) at > 60 mg/kg)./GENOTOXICITY/ Oxidized CrVI (chromic acid, potassium chromate, sodium chromate, potassium dichromate, sodium dichromate) and CrIII (Cr-chloride, Cr-nitrate, Cr-potassium sulfate, Cr-acetate) were tested on baby hamster kidney (BHK) and Chinese hamster ovary (CHO) cell lines for cytotoxic and cytogenetic effects. Results showed CrVI compounds had inhibiting doses (50%) at 100 - 375 times lower than those of CrIII compounds with BHK cells. LD50 for CrVI compounds was more than 1250 fold lower than LD50 for CrIII with CHO cells. In CHO cells, there was a significant increase in sister chromatid exchange (SCE) with CrVI compounds. CrVI at 0.25 to 1 ug/mL reduced cell growth by 300-fold and survival (as indicated by DNA and RNA synthesis) with BHK cells. The frequency of SCE (1.5 - 2.1-fold) and chromosome aberrations (3.3 - 9.9-fold) was increased in CHO cells when CrVI and CrIII (SCE = 1.0-1.1-foldCA = 1.2 - 2.3-fold) compounds were used, when compared to controls.For more Non-Human Toxicity Excerpts (Complete) data for CHROMIC ACID (6 total), please visit the HSDB record page. |
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| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
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| Clean Water Act Anforderungen | Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Chromium and compounds/ |
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| State Drinking Water Standards | (CA) CALIFORNIA 10 ug/L /Hexavalent Chromium/ |
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| Federal Drinking Water Standards | EPA 100 ug/L |
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