HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Fosfosal
FOSFOSAL · ur1522 · ur1521 · disdolen · salicylphosphate · phosphonoxybenzoicacid · SALICYLIC ACID PHOSPHATE · 2-phosphonoxybenzoicacid
Identifikatoren & physikalische Daten
| CAS No. | 6064-83-1 |
|---|---|
| Summenformel | C7H7O6P |
| Durchschnittliche Molmasse | 218,1 g/mol |
| Monoisotopische Masse | 217,99802494 g/mol |
| SMILES | O=C(O)c1ccccc1OP(=O)(O)O |
| InChIKey | FFKUDWZICMJVPA-UHFFFAOYSA-N |
| PubChem CID | 3418 |
| ChEMBL | CHEMBL287275 |
| ChEBI | CHEBI:94564 |
| EC No. | 227-993-5 |
| DTXSID | DTXSID9045394 |
| Lokaler Name | Fosfosal |
Chemische & physikalische Eigenschaften
| XLogP | 0 |
|---|---|
| Polarare Oberfläche (TPSA) | 104 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 14 |
| Formalladung | 0 |
| Komplexität | 259 |
| Schmelzpunkt | 162-166°C |
| Siedepunkt | 482.3±47.0 °C(Predicted) |
| Dichte | 1.695±0.06 g/cm3(Predicted) |
| Lagerbedingungen | −20°C |
| pKa (Säurekonstante) | 1.06±0.30(Predicted) |
| Aggregatzustand | solid |
| Farbe | White to off-white |
| Löslichkeit | Soluble in water. |
| Merck | 14,4255 |
| BRN | 2619142 |
| CAS Datenbank | 6064-83-1(CAS DataBase Reference) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| Zollcode | 2919900090 |
| RTECS-Nr. | VO2770000 |
| R-Sätze (R) | 22-36/37/38 |
| Toxizität | LD50 in male, female mice, male, female rats at pH 1.0, aq soln (mg/kg): 94, 105, 153, 257 i.v.352, 253, 338, 360 i.p.1455, 1539, 1104, 1213 orallyat pH 3.5 (mg/kg): 117, 118, 207, 215 i.v.1592, 1483, 1085, 1128 i.p.1702, 2007, 1685, 2225 orally (Sanchez) |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 26-36 |
Anwendungen & Verwendung
Beschreibung
Fosfosal is a highly water soluble salicylate useful in the treatment of musculoskeletal and arthritic pain. Unlike aspirin, it does not inhibit prostaglandin synthesis or platelet aggregation.
Verwenden
2-Carboxyphenyl phosphate is used as a substrate for the estimation of acid phosphatase. It is also used as a analgesic, anti-inflammatory agent.