HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lorglumide
cr1409 · LORGLUMIDE · IEKOTSCYBBDIJC-UHFFFAOYSA-N · LORGLUMIDE SODIUM SALT (CR 1409) NON-PEP TIDE CCK ANTAG · d,l-4-(3,4-dichlorobenzoylamino)-5-(dipentylamino)-5-oxo-pentanoicacid · 4-dichlorobenzoyl)amino)-5-(dipentylamino)-5-oxo-4-(((+-)-pentanoicaci · Pentanoic acid, 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo- · (±)-4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoic acid sodium salt
Identifikatoren & physikalische Daten
| CAS No. | 97964-56-2 |
|---|---|
| Summenformel | C22H32Cl2N2O4 |
| Durchschnittliche Molmasse | 459,4 g/mol |
| Monoisotopische Masse | 458,17391286 g/mol |
| SMILES | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 |
| InChIKey | IEKOTSCYBBDIJC-UHFFFAOYSA-N |
| PubChem CID | 3960 |
| ChEMBL | CHEMBL24938 |
| ChEBI | CHEBI:88307 |
| DTXSID | DTXSID2046961 |
Chemische & physikalische Eigenschaften
| XLogP | 5,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 86,7 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 14 |
| Schwere Atome | 30 |
| Formalladung | 0 |
| Komplexität | 537 |
| Siedepunkt | 621.4±55.0 °C(Predicted) |
| Dichte | 1.195±0.06 g/cm3(Predicted) |
| Löslichkeit | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >10 mg/mL |
| pKa (Säurekonstante) | 4.47±0.10(Predicted) |
| Aggregatzustand | solid |
| Farbe | white |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 2 |
|---|---|
| RTECS-Nr. | SA3680700 |
Anwendungen & Verwendung
Verwenden
Lorglumide is a specific cholecytokinin receptor antagonist. It is also an intermediate in synthesizing Lorglumide Sodium Salt (L469910), a nonpeptidic antagonist of the CCK A receptor, and minimally effective at the CCK B receptor. It blocks CCK -mediated muscle contraction, pancreatic growth and secretion.