Efo-dine
PVP-I · polyvinyl · POLYVINYLPYRROLIDONE IODINE · betadine · PVP-IODINE · iodopovidone · inadine · disadined.p.
Identifikatoren & physikalische Daten
| CAS No. | 25655-41-8 |
|---|---|
| Summenformel | C6H9I2NO |
| Durchschnittliche Molmasse | 364,95 g/mol |
| SMILES | C=CN1CCCC1=O.II |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| PubChem CID | 410087 |
| ChEMBL | CHEMBL5424182 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 20,3 |
|---|---|
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 120 |
| Schmelzpunkt | 300 °C |
| Lagerbedingungen | Keep in dark place,Inert atmosphere,Room temperature |
| Löslichkeit | H2O: soluble100mg/mLSoluble in water, ethyl alcohol, isopropyl alcohol, polyethylene glycol and glycerol. Insoluble in chloroform, carbon tetrachloride, hexane, acetone and petroleum ether. |
| Aggregatzustand | Powder |
| Farbe | Yellow-brown |
| Geruch | ylsh. brn. amorphous powd., sl. char. odor |
| Merck | 13,7784 |
| Kosmetik-Inhaltsstoffe Funktionen | ANTIMICROBIAL |
| InChI | InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)81-2/h2H,1,3-5H2 |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| SMILES | II.C(N1CCCC1=O)=C |
| CAS Datenbank | 25655-41-8(CAS DataBase Reference) |
| EPA chemische Informationen | Povidone-iodine (25655-41-8) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 2 |
|---|---|
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29339900 |
| RTECS-Nr. | TR1579600 |
| Sicherheitshinweise (S) | 24/25-22 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 25655-41-8(Hazardous Substances Data) |
| Gefahrenklasse | Aquatic Chronic 2Eye Dam. 1Skin Irrit. 2 |
Anwendungen & Verwendung
Beschreibung
Povidone iodine is iodophor, used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. A 10% povidone iodine solution contains 1% available iodine, but free-iodine is at 0.1% concentration. Skin exposure causes irritant rather than allergic contact dermatitis. In such a situation, however, iodine seems to be the true hapten.
History
Povidone iodine (PI) is frequently used during surgical preparation, postoperative wound cleaning and dressing. It was described by Shelaski about seventy years ago (Shelanski and Shelanski, 1956). PI consists of the complex structure of povidone, a polymer that is structurally similar to plasma proteins, and the iodine element, which has antimicrobial properties. The function of polyvinylpyrrolidone (PVP) used as a polymer includes increasing iodine solubility and penetration, decreasing iodine ion concentration and keeping iodine bound. However, PVP does not have antimicrobial properties. Shelanski defined this complex structure as 'iodophor' (Shelanski and Shelanski, 1956).
Herstellung & Synthese
synthetische
Povidone Iodine Solution is an antiseptic and disinfectant agent. The preparation method of povidone iodine: be that 1.17% potassium iodide is dissolved in part water in 10% water by mass percent, 2.34% iodine is added to wherein stirring and dissolving, be mixed with iodine solution standby; 0.01% stability auxiliary agent is dissolved in part water 10% water standby; In complex reaction still, add remaining water, open and stir, dropping into 10.0% polyvinylpyrrolidone k30 dissolves, then substep adds above-mentioned two kinds of solution that prepare, finally add 7.5% solvent normal propyl alcohol, after feeding intake, allow reactant mixture at 20 ℃, react 2 hours, react complete mixture is lowered the temperature and obtained betagen solution.