Grundinformationen
- Standard-SMILES
C=CCN1CCCC1CNC(=O)c1cc2n[nH]nc2cc1OC- InChIKey
KSEYRUGYKHXGFW-UHFFFAOYSA-N- Summenformel
- C16H21N5O2
- Durchschnittliche Molmasse
- 315,37 g/mol
- Monoisotopische Masse
- 315,16952491
Überblick
Alizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects. This kind of pharmacological activity makes it effective for use in the treatment of various kinds of nausea and vomiting, including that which may occur postoperatively.
Namen und Bezeichner
- Bevorzugter Name
- 6-Methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide
- IUPAC
- 6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide
Namen und Synonyme
6-Methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamideNausilexUNII-P55703ZRZYSCHEMBL48936orb1689218SCHEMBL1649436SCHEMBL30089955GTPL11141KSEYRUGYKHXGFW-UHFFFAOYSA-NHY-A0125EINECS 261-710-6BRN 6432438
Weitere Namen anzeigen
AC-22579DB-053369CS-0017442NS00009083T60813Q6318291H-Benzotriazole-5-carboxamide, 6-methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-6-Methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1H-benzotriazole-5-carboxamide
Datenbank-Bezeichner
- CAS
59338-93-1- PubChem CID
- 43008
- DTXSID
DTXSID10866755- Nikkaji
- J10.911H
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,5
- Polarare Oberfläche (TPSA)
- 83,1 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 23
- Formalladung
- 0
- Komplexität
- 433
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals
LogP
1.79
2.22
Solubility4.95e-01 g/L
Melting Point139 °C
Physical DescriptionSolid
Chemie und Industrie
Pharmakologische Informationen
PharmacodynamicsAlizapride is a dopamine antagonist.
Mechanism of Action
The anti-emetic action of Alizapride is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the central nervous system (CNS)—this action prevents nausea and vomiting triggered by most stimuli. Structurally similar to metoclopramide and, therefore, shares similar other atributres related to emesis and prokinetics.
Biological Half-Life3 hours
Absorption, Distribution and Excretionrenal
Cellular LocationsMembrane
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