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HCID 443953Erstellt: 23. Oktober 2026

Erythromycinethylsuccinat

Esinol · Evesin · Refkas · Anamycin · Arpimycin · E-Mycin e · Eryliquid · Monomycin

https://huagongshe.com/de/chemical/443953

Molekülstruktur von Erythromycinethylsuccinat

Identifikatoren & physikalische Daten

CAS No.1264-62-6
SummenformelC43H75NO16
Durchschnittliche Molmasse862,1 g/mol
Monoisotopische Masse861,50858532 g/mol
SMILESCCOC(=O)CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C
InChIKeyNSYZCCDSJNWWJL-YXOIYICCSA-N
PubChem CID443953
ChEMBLCHEMBL1200688
ChEBICHEBI:31555
EC No.215-033-8
DTXSIDDTXSID4022993
Lokaler NameErythromycinethylsuccinat

Chemische & physikalische Eigenschaften

XLogP3,4
Polarare Oberfläche (TPSA)226
H-Brücken-Donoren4
H-Brücken-Akzeptoren17
Frei drehbare Bindungen14
Schwere Atome60
Formalladung0
Komplexität1.450
ArzneimittelPharmaceuticals -> Antibiotics
LipidePolyketides [PK] -> Ansamycins and related polyketides [PK05]
GeruchODORLESS OR PRACTICALLY SO
GeschmackPRACTICALLY TASTELESS
Color/FormWHITE OR SLIGHTLY YELLOW, CRYSTALLINE POWDER
LöslichkeitFREELY SOL IN ACETONE & CHLOROFORMSOL IN 95% ETHANOL & BENZENESPARINGLY SOL IN ETHERVERY SLIGHTLY SOL IN WATERFREELY SOLUBLE IN ALC, SOL IN POLYETHYLENE GLYCOLethanol: soluble50mg/mLFreely soluble in organic solvents, practically insoluble in water
Human DrugsFDA approved drugs -> Active ingredient
BrechungsindexINDEX OF REFRACTION: 1.490 (ALPHA), 1.515 (BETA), 1.567 (GAMMA)1.5280 (estimate)
Stability/Shelf LifeAFTER RECONSTITUTION OF COMMERCIALLY AVAILABLE POWDER, SUSPENSIONS ARE STABLE FOR 10 DAYS @ 2-8 °CCOMMERCIALLY AVAILABLE TABLETS & POWDER FOR ORAL SUSPENSION HAVE EXPIRATION DATES OF 2 YR FOLLOWING DATES OF MANUFACTURECOMMERCIALLY AVAILABLE SUSPENSIONS HAVE EXPIRATION DATES OF 18 MONTHS FOLLOWING DATES OF MANUFACTUREERYTHROMYCIN ETHYLSUCCINATE IM INJECTION HAS AN EXPIRATION DATE OF 18 MONTHS FOLLOWING DATE OF MFR
Dissociation ConstantsPKA 7.1
Collision Cross Section257.7 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
Schmelzpunkt219-224 C
Siedepunkt778.19°C (rough estimate)
Dichte1.1417 (rough estimate)
Flammpunkt>110°(230°F)
LagerbedingungenSealed in dry,Room Temperature
Aggregatzustandsolid
pKa (Säurekonstante)13.09±0.70(Predicted)
Farbewhite
StabilitätHygroscopic
Hauptanwendungenpharmaceuticalpharmaceutical small molecule
InChIKeyNSYZCCDSJNWWJL-UHFFFAOYSA-N
SMILESC1(OC(=O)CCC(OCC)=O)C(N(C)C)CC(C)OC1OC1C(CC(C(C(C(O)C(O)(C)C(CC)OC(=O)C(C)C(OC2OC(C)C(O)C(C)(OC)C2)C1C)C)=O)C)(O)C
CAS Datenbank1264-62-6

Sicherheit & Vorschriften

GHS-EinstufungDangerH317 (29.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]P233, P260, P261, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P321, P333+P317, P337+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 144 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Weitere SicherheitsinformationenIMAP assessments - Erythromycin, 2'-(ethyl butanedioate): Environment tier I assessment
Hazard Classes and CategoriesSkin Sens. 1 (29.9%)
Human Toxicity ExcerptsAMONG HYPERSENSITIVITY REACTIONS ARE FEVER, EOSINOPHILIA, & SKIN ERUPTIONS, EACH OF WHICH MAY OCCUR ALONE OR IN COMBINATIONTHEY DISAPPEAR SHORTLY AFTER THERAPY IS STOPPED. ...MAY PRODUCE IRRITATIVE EFFECTS. ORAL ADMIN...FREQUENTLY ACCOMPANIED BY EPIGASTRIC DISTRESS, WHICH MAY BE QUITE SEVERE. /ERYTHROMYCIN/IM INJECTION OF QUANTITIES LARGER THAN 100 MG PRODUCES...SEVERE PAIN... PERSISTS FOR HR: IV PERFUSIONS OF 1-G DOSES...ALMOST REGULARLY IS FOLLOWED BY THROMBOPHLEBITIS. ...6 PT...DEVELOPED DIFFICULTY IN HEARING WHILE BEING TREATED WITH 4 G/DAY...IV. ... CESSATION...LED TO COMPLETE RETURN OF NORMAL HEARING... /ERYTHROMYCIN/A CASE REPORT OF HEPATOTOXICITY RESULTING FROM ERYTHROMYCIN ETHYLSUCCINATE THERAPY IN 60-YR-OLD FEMALE IS DESCIRBED.
Wassergefährdungsklasse (WGK)2
Zollcode29419000
RTECS-Nr.WM9800000
R-Sätze (R)42/43-36/37/38
ToxizitätLD50 oral in mouse: > 10gm/kg
GefahrensymboleXn,Xi
Sicherheitshinweise (S)36-26
Lagerklasse11 - Combustible Solids
Gefahrstoffdaten1264-62-6(Hazardous Substances Data)
GefahrenklasseResp. Sens. 1Skin Sens. 1