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Alpidem
IMidazo · ALPIDEM · inanxyl · Ananxyl · Alpidemum · SL-80．0342 · SL 80.0342-00 · Unii-I93sc245qz
Identifikatoren & physikalische Daten
| CAS No. | 82626-01-5 |
|---|---|
| Summenformel | C21H23Cl2N3O |
| Durchschnittliche Molmasse | 404,3 g/mol |
| Monoisotopische Masse | 403,12181772 g/mol |
| SMILES | CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12 |
| InChIKey | JRTIDHTUMYMPRU-UHFFFAOYSA-N |
| PubChem CID | 54897 |
| ChEMBL | CHEMBL54349 |
| ChEBI | CHEBI:135649 |
| EC No. | 689-420-9 |
| DTXSID | DTXSID8049046 |
Chemische & physikalische Eigenschaften
| XLogP | 4,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 37,6 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 27 |
| Formalladung | 0 |
| Komplexität | 478 |
| Schmelzpunkt | 136-138°C |
| Dichte | 1.24±0.1 g/cm3(Predicted) |
| Lagerbedingungen | Refrigerator |
| Löslichkeit | DMSO: ≥10mg/mL |
| pKa (Säurekonstante) | 4.74±0.50(Predicted) |
| Aggregatzustand | powder |
| Farbe | white to tan |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)AlpidemvMost-DILI-concern8WithdrawnDOI:10.1016/j.drudis.2016.02.015 |
| Alarmwort | Warnung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
Anwendungen & Verwendung
Beschreibung
Alpidem is an imidazopyridine antianxiety agent with anticonvulsant properties. It is claimed to be the first non-benzodiazepine anxiolytic to show selectivity for the omega-1 modulatory site of the GABA, receptors. Alpidem is reported to be superior to buspirone and similar to the benzodiazepines, but is significantly better tolerated with lower abuse potential.
Verwenden
A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic