Rufloxacin

HCID 58258CAS 101363-10-4
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Grundinformationen

Standard-SMILES
CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2SCC4)CC1
InChIKey
NJCJBUHJQLFDSW-UHFFFAOYSA-N
Summenformel
C17H18FN3O3S
Durchschnittliche Molmasse
363,4 g/mol
Monoisotopische Masse
363,10529066

Überblick

Rufloxacin is a member of quinolines, a quinolone antibiotic and a fluoroquinolone antibiotic.

Namen und Bezeichner

Bevorzugter Name
Rufloxacin
IUPAC
7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

Namen und Synonyme

Rufloxacin101363-10-4RufloxacineRufloxacinoRufloxacinumMF 934MonosNSC-7598357-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acidY521XM2900DTXSID6048412Tebraxin
Weitere Namen anzeigen
9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7h-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acidrufloxacinaUroflox7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo(7.3.1.0^(5,13))trideca-5(13),6,8,11-tetraene-11-carboxylic acid7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo(7.3.1.05,13)trideca-5(13),6,8,11-tetraene-11-carboxylic acid7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-(1,4)thiazino(2,3,4-ij)quinoline-6-carboxylic acidRefChem:180288

Datenbank-Bezeichner

CAS
101363-10-4
PubChem CID
58258
DTXSID
DTXSID6048412
ChEMBL
CHEMBL295619
ChEBI
CHEBI:8909
UNII
Y521XM2900
EC Number
842-241-1
Nikkaji
J365.971B

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-0,3
Polarare Oberfläche (TPSA)
89,4 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
8
Frei drehbare Bindungen
2
Schwere Atome
25

Experimentelle und physikochemische Eigenschaften

Drugs · 3 Einträge

Pharmaceuticals -> Antibiotics

Pharmaceuticals -> Listed in ZINC15

Pharmaceuticals -> Anti infectives for systemic use -> Antibacterials for systemic use

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

J - Antiinfectives for systemic use

QJ - Antiinfectives for systemic use

Mechanism of ActionRufloxacin is a fluoroquinolone antibacterial that inhibits bacterial DNA gyrase, blocking DNA supercoiling and replication.
MeSH Pharmacological Classification · 1 Eintrag

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

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