HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Propacetamol
Propacetamo · Pro-Dafalgan · PROPACETAMOL · Propacatemol · Propacetamol USP/EP/BP · 4-Acetamidophenyl N,N-diethylglycinate · 4-acetamidophenyl N,N-diethylaminoacetate · N，N-Diethylglycine 4-(acetylamino)phenyl ester
Identifikatoren & physikalische Daten
| CAS No. | 66532-85-2 |
|---|---|
| Summenformel | C14H20N2O3 |
| Durchschnittliche Molmasse | 264,32 g/mol |
| Monoisotopische Masse | 264,1473925 g/mol |
| SMILES | CCN(CC)CC(=O)Oc1ccc(NC(C)=O)cc1 |
| InChIKey | QTGAJCQTLIRCFL-UHFFFAOYSA-N |
| PubChem CID | 68865 |
| ChEMBL | CHEMBL1851805 |
| ChEBI | CHEBI:135089 |
| EC No. | 266-390-1 |
| DTXSID | DTXSID3057800 |
| Lokaler Name | Propacetamol |
Chemische & physikalische Eigenschaften
| XLogP | 1,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 58,6 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 19 |
| Formalladung | 0 |
| Komplexität | 295 |
| Stoffklassen | Other Uses -> Pharmaceuticals |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Löslichkeit | SolubleH2O : 100 mg/mL (378.33 mMNeed ultrasonic) |
| Siedepunkt | 434.5ºC at 760 mmHg434.5±30.0 °C(Predicted) |
| Schmelzpunkt | 55-57 °C |
| Dichte | 1.132±0.06 g/cm3(Predicted) |
| Lagerbedingungen | Store at -20°C |
| pKa (Säurekonstante) | 14.20±0.70(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White to off-white |
| CAS Datenbank | 66532-85-2(CAS DataBase Reference) |
Sicherheit & Vorschriften
| Gefahrenübersicht | Allergic contact dermatitis reported in nurses (contact and airborne dermatitis)[Kanerva, p. 1829] |
|---|---|
| Unerwünschte Wirkungen | Skin Sensitizer - An agent that can induce an allergic reaction in the skin. |
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)PropacetamolDILI PositiveDOI:10.1016/j.drudis.2019.09.022 |
Anwendungen & Verwendung
Beschreibung
Propacetamol is the prodrug of paracetamol (acetaminophen), used for intravenous administration. It results from eombination of paracetamol and diethylglycine. Causes contact dermatitis and airborne dermatitis in nurses. Allergenic properties are due to the N,N' -diethylglycine moiety, and not to the paracetamol moiety.
Verwenden
Propacetamol hydrochloride is a water-soluble prodrug for intravenous administration resulting in the liberation of paracetamol.