HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(2R)-2-Amino-3,3-dimethylbutan-1-ol
(R)-(-)-TERT-LEUCINOL · (2R)-2-Amino-3,3-dimethylbutan-1-ol · H-D-TLE-OL · D-T-LEUCINOL · D-Tert-Leucinol · H-D-(TBU)GLY-OL · (R)-TERT-LEUCINOL · D-T-BUTYLGLYCINOL
Identifikatoren & physikalische Daten
| CAS No. | 112245-09-7 |
|---|---|
| Summenformel | C6H15NO |
| Durchschnittliche Molmasse | 117,19 g/mol |
| Monoisotopische Masse | 117,1153641 g/mol |
| SMILES | CC(C)(C)[C@@H](N)CO |
| InChIKey | JBULSURVMXPBNA-YFKPBYRVSA-N |
| PubChem CID | 6932847 |
| EC No. | 634-525-7 |
| DTXSID | DTXSID60426146 |
Chemische & physikalische Eigenschaften
| XLogP | 0,4 |
|---|---|
| Polarare Oberfläche (TPSA) | 46,3 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 8 |
| Formalladung | 0 |
| Komplexität | 65 |
| Schmelzpunkt | 30-33 °C(lit.) |
| Siedepunkt | 70 °C0.4 mm Hg(lit.) |
| Dichte | 0.9 g/mL at 25 °C(lit.) |
| Flammpunkt | 194 °F |
| Lagerbedingungen | Keep in dark place,Inert atmosphere,2-8°C |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | 12.88±0.10(Predicted) |
| Farbe | Colorless to yellow |
| Hauptanwendungen | peptide synthesis |
| InChI | InChI=1S/C6H15NO/c1-6(2,3)5(7)4-8/h5,8H,4,7H2,1-3H3/t5-/m0/s1 |
| InChIKey | JBULSURVMXPBNA-YFKPBYRVSA-N |
| SMILES | C(O)[C@H](N)C(C)(C)C |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 45 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%)Eye Irrit. 2 (100%)STOT SE 3 (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 2922190090 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
Anwendungen & Verwendung
Verwenden
(R)-Tert-leucinol (H-D-Tle-ol) is a chiral molecular compound with optical activity and its enantiomeric form is (S)-tert-leucinol. (R)-Tert-leucinol belongs to the class of α-amino alcohols, which have certain biological activities and are potent reversible inhibitors of protein synthesis. (R)-Tert-leucinol can be used as a chiral ligand for asymmetric catalytic reactions. Its derivatives are also used as optical splitting reagents, for peptidyl alcohol synthesis in peptide drugs, and as inhibitors of protein hydrolysis.