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1,1-Dimethoxytrimethylamin
DMF-DMA · Dimethoxy-N,N-dimethylmethanamine · 1,1-dimethoxy-n,n-dimethyl-methanamin · (Dimethylamino)dimethoxymethane · DMF-DIMETHYLACETAL · 1,1-DIMETHOXYTRIMETHYLAMINE · 1,1-DIMETHOXY-N,N-DIMETHYLMETHYLAMINE · N,N-Dimethylformamide dimethyl
Identifikatoren & physikalische Daten
| CAS No. | 4637-24-5 |
|---|---|
| Summenformel | C5H13NO2 |
| Durchschnittliche Molmasse | 119,16 g/mol |
| Monoisotopische Masse | 119,09462866 g/mol |
| SMILES | COC(OC)N(C)C |
| InChIKey | ZSXGLVDWWRXATF-UHFFFAOYSA-N |
| PubChem CID | 78373 |
| ChEBI | CHEBI:85061 |
| EC No. | 225-063-3 |
| DTXSID | DTXSID3063540 |
| Lokaler Name | 1,1-Dimethoxytrimethylamin |
Chemische & physikalische Eigenschaften
| XLogP | 0,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 21,7 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 8 |
| Formalladung | 0 |
| Komplexität | 52,4 |
| Stoffklassen | Nitrogen Compounds -> Other Nitrogen Compounds |
| Dampfdruck | 30.0 [mmHg]34.5hPa at 20℃ |
| Physical Description | Colorless liquid with a rancid odor[BASF MSDS] |
| Schmelzpunkt | -85°C |
| Siedepunkt | 102-103 °C/720 mmHg (lit.) |
| Dichte | 0.897 g/mL at 25 °C (lit.) |
| Brechungsindex | n20/D 1.396(lit.) |
| Flammpunkt | 45 °F |
| Lagerbedingungen | Store below +30°C. |
| Löslichkeit | Miscible with most organic solvents.hydrolysis |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 5.00±0.50(Predicted) |
| Farbe | White to off-white |
| pH | 7 (H2O) |
| Explosionsgrenze | 1.3-17.7%(V) |
| BRN | 506020 |
| InChI | 1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3 |
| InChIKey | ZSXGLVDWWRXATF-UHFFFAOYSA-N |
| SMILES | COC(OC)N(C)C |
| LogP (Verteilungskoeffizient) | 0.750 (est) |
| CAS Datenbank | 4637-24-5(CAS DataBase Reference) |
| NIST chemische Informationen | Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5) |
| EPA chemische Informationen | Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 230 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Methanamine, 1,1-dimethoxy-N,N-dimethyl-Status: Active Update: 13-01-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/11035Dimethylformamide-dimethylacetal: Does not have an individual approval but may be used under an appropriate group standard |
| Gefahrenübersicht | An irritantMay cause skin sensitizationHarmful by inhalation[BASF MSDS] See Dimethylformamide. See 1,1-Dimethoxyethane. |
| Hazard Classes and Categories | Flam. Liq. 2 (100%) |
| Unerwünschte Wirkungen | Skin Sensitizer - An agent that can induce an allergic reaction in the skin. |
| Toxicity Data | LC50 (rat) = 12,160 mg/m3/4hr |
| F | 21 |
| Wassergefährdungsklasse (WGK) | 1 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 3271 3/PG 2 |
| Zollcode | 29225000 |
| R-Sätze (R) | 11-22-36/37/38-36/38-20-20/21/22-10-52 |
| Toxizität | LD50 orally in Rabbit: > 5000 mg/kg |
| Gefahrensymbole | F,Xn,Xi |
| Sicherheitshinweise (S) | 16-26-36/37-36/37/39-33-29-7/9 |
| Gefahrenklasse | 3Acute Tox. 4 InhalationEye Dam. 1Flam. Liq. 2Skin Sens. 1 |
| Verpackungsgruppe | II |
| Lagerklasse | 3 - Flammable liquids |
| Selbstentzündungstemperatur | 155 °C |
Anwendungen & Verwendung
Verwenden
N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.