Bucladesin
Bucladesin · BUCLADESINE · N-(9-beta-D-Ribofura · Cyclic AMP dibutyrate · Dibutyryl cyclic 3',5'-AMP · Dibutyryl 3',5'-Cyclic AMP · CalciuM Dibutyacyladenosine · 3',5'-Cyclic AMP dibutyrate
Identifikatoren & physikalische Daten
| CAS No. | 362-74-3 |
|---|---|
| Summenformel | C18H24N5O8P |
| Durchschnittliche Molmasse | 469,4 g/mol |
| Monoisotopische Masse | 469,13624974 g/mol |
| SMILES | CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC |
| InChIKey | CJGYSWNGNKCJSB-YVLZZHOMSA-N |
| PubChem CID | 9687 |
| ChEMBL | CHEMBL485980 |
| ChEBI | CHEBI:50095 |
| EC No. | 206-649-8 |
| DTXSID | DTXSID1040459 |
| Lokaler Name | Bucladesin |
Chemische & physikalische Eigenschaften
| XLogP | -0,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 164 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 11 |
| Frei drehbare Bindungen | 8 |
| Schwere Atome | 32 |
| Formalladung | 0 |
| Komplexität | 759 |
| Collision Cross Section | 215.3 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]210.36 Ų [M+Na]+ [CCS Type: TW214.52 Ų [M+H]+ [CCS Type: TW214.45 Ų [M+K]+ [CCS Type: TW |
| Dichte | 1.72±0.1 g/cm3(Predicted) |
| Lagerbedingungen | -20°C Freezer |
| Löslichkeit | DMSOMethano |
| pKa (Säurekonstante) | 0.82±0.60(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White |
Sicherheit & Vorschriften
| Weitere Sicherheitsinformationen | IMAP assessments - Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate: Environment tier I assessmentIMAP assessments - Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate: Human health tier I assessment |
|---|---|
| Alarmwort | Warnung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
Anwendungen & Verwendung
Beschreibung
Bucladesine is a cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)
Verwenden
Bucladesine is a cell permeable cAMP analog. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions. cAMP is only able to elicit minimal responses in these situations. The neurite outgrowth instigated by bucladesine in cell cultures has been shown to be enhanced by nardosinone.