Nerol → Beta-citronellol, (S)-

Beteiligte Stoffe

Reaktionsschritte

In a 100 ml stainless steel-made autoclave whose atmosphere had been displaced with nitrogen were charged 1.54 g (10 mmole) of nerol, 0.0837 g (0.1 mmole) of Rh(COD)((+)-cBINAP)Cl obtained in Example 4, and 10 ml of benzene, and hydrogenation reaction was carried out at room temperature and at a hydrogen pressure of 30 kg/cm2 for 17 hours. There was obtained 1.46 g of (S)-(-)-citronellol at a conversion of 99% and a selectivity of 99%. From the results of optical rotation [α]25D =-3.65° (c=10.1, chloroform), the optical yield was found to be 70%ee.

Herkunft & Nachweise