HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | N-Boc-4,4-difluoro-L-proline methyl ester | HCID 11129200 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate | HCID 45082563 | — |
Reaktionsschritte
(S)-1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate (0.472 g) in CH2Cl2 (1 mL) was treated with trifluoroacetic acid (1.4 mL), stirred at ambient temperature for 4 hours, and concentrated. The product was free-based using a MEGA BE-SCX column with 1:1 CH2Cl2/methanol as eluent for the trifluoroacetic acid. The product was released from the column with 5% (7 M ammonia in methanol) in CH2Cl2 as eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08546399B2 |
| Quelldatensatz | uspto-grants-2013_10 |
| ORD ID | ord-b635a8837e8847eca488274e5fbc6221 |
| Quellennotiz | uspto-grants-2013_10 |