HCID 178418777, Verbindung → HCID 178418696, Verbindung

HRID 10573

Reaktionsgleichung

Reaktionsgleichung von HRID 10573
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([CH:26]=[CH2:27])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pt]=O>[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([CH2:26][CH3:27])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 178418777HCID 178418777, Verbindung

Produkt 1

HCID 178418696HCID 178418696, VerbindungAusbeute 45,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of Intermediate 124 (90.5 mg) in methanol (5 ml) was added with platinum oxide (13 mg, Wako Pure Chemical Industries) and stirred for 15 hours under hydrogen atmosphere. The reaction mixture was filtered through a Celite layer, and the solvent was evaporated under reduced pressure. Then, the residue was purified by silica gel column chromatography (chloroform:methanol=20:1) to obtain the title compound (41.1 mg).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through a Celite layer
  2. customthe solvent was evaporated under reduced pressure
  3. customThen, the residue was purified by silica gel column chromatography (chloroform:methanol=20:1)

Quellen und Nachweise

ORD-Eintrag
ord-41aab4904af540338d435ca329ed8c84
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

Verknüpfte Notizen

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