HCID 23713292, Verbindung → 6-chloropyridine-2-sulfonic Acid

HRID 1074218

Reaktionsgleichung

Reaktionsgleichung von HRID 1074218
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([O-:11])(=[O:10])=[O:9])[N:3]=1.[Na+]>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([OH:11])(=[O:10])=[O:9])[N:3]=1

Komponenten

3

Edukt 1

HCID 23713292HCID 23713292, Verbindung

Produkt 1

HCID 27628906-chloropyridine-2-sulfonic AcidAusbeute 96,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

Into 0.82 g (3.8 mmol) of sodium 2-chloropyridine-6-sulfonate prepared in accordance with Example 1, 10 ml of concentrated hydrochloric acid was added, and the mixture was stirred at room temperature overnight. Then, the solvent was distilled off, and after an addition of 200 ml of 2-propanol, the residue was heated. Insoluble matters were removed by filtration, and the filtrate was distilled under reduced pressure to obtain 710 mg (96.6%) of 2-chloropyridine-6-sulfonic acid as crystalline solid. Purification was conducted by recrystallization from 2-propanol.

Aufarbeitung

  1. additionwas added
  2. distillationThen, the solvent was distilled off
  3. additionafter an addition of 200 ml of 2-propanol
  4. temperaturethe residue was heated
  5. customInsoluble matters were removed by filtration
  6. distillationthe filtrate was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-aa9c7b4c6d564749855d4a6a05427629
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04973697

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