HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Boron tribromide → 5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Boron tribromide | HCID 25134 | — |
| Edukt | 5-[2-(2-chloro-4-methoxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one | HCID 66699498 | — |
| Produkt | 5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one | HCID 66699301 | — |
Reaktionsschritte
In analogy to Example 147, step 5, 5-[2-(2-chloro-4-methoxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one was reacted with BBr3 to give the title compound as a colorless solid. MS (m/e)=376.2 [M+H+].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08138189B2 |
| Quelldatensatz | uspto-grants-2012_03 |
| ORD ID | ord-256203201fef4414831958d80fe41e8c |
| Quellennotiz | uspto-grants-2012_03 |