HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dabco → 6-{3-Chloro-4-[2-(1,5-dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxy}-4-trifluoromethyl-nicotinic acid methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dabco | HCID 9237 | — |
| Edukt | Methyl 6-chloro-4-(trifluoromethyl)nicotinate | HCID 2775340 | — |
| Edukt | 5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one | HCID 66699301 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 6-{3-Chloro-4-[2-(1,5-dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxy}-4-trifluoromethyl-nicotinic acid methyl ester | HCID 72310563 | — |
Reaktionsschritte
In analogy to Example 163, 5-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one (Example 203, step 5) was reacted with methyl-6-chloro-4-(trifluoromethyl)-nicotinate in the presence of triethylamine and 1,4-diazabicyclo[2.2.2]octane to give the title compound as an off-white solid. MS (m/e)=579.3 [M+H+].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08138189B2 |
| Quelldatensatz | uspto-grants-2012_03 |
| ORD ID | ord-2f918ac976db4bc4a96ce6e7e2182550 |
| Quellennotiz | uspto-grants-2012_03 |