Ethanolamine → 1-(2-Hydroxyethylamino)-3-[10-(2-ethylhexyloxy)decyloxy]-2-propanol

HRID 1098

Reaktionsgleichung

Reaktionsgleichung von HRID 1098
[CH2:1]([CH2:3][NH2:4])[OH:2].[CH2:5]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH2:21][CH:22]([CH2:27][CH3:28])[CH2:23][CH2:24][CH2:25][CH3:26])[CH:6]1[O:8][CH2:7]1>C(O)C>[OH:2][CH2:1][CH2:3][NH:4][CH2:7][CH:6]([OH:8])[CH2:5][O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH2:21][CH:22]([CH2:27][CH3:28])[CH2:23][CH2:24][CH2:25][CH3:26]

Komponenten

4

Edukt 2

HCID 700EthanolamineHCID 1969463510-(2-Ethylhexyloxy)decyl glycidyl ether

Produkt 1

HCID 98659041-(2-Hydroxyethylamino)-3-[10-(2-ethylhexyloxy)decyloxy]-2-propanolAusbeute 68,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A 200-ml two-necked flask equipped with a stirrer, reflux tube and dropping funnel was charged with 32.7 g (0.54 mol) of ethanolamine and 10.1 g of ethanol. While heating and stirring the mixture at 80° C., 1.76 g (5.14 mmol) of 10-(2-ethylhexyloxy)decyl glycidyl ether were added dropwise over 2 hours. After the resultant mixture was heated and stirred further for 18 hours, it was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 1.42 g (yield: 68%) of the title compound (Ia-14).

Aufarbeitung

  1. customA 200-ml two-necked flask equipped with a stirrer
  2. temperaturereflux tube
  3. temperatureWhile heating
  4. stirringstirred further for 18 hours
  5. concentrationit was concentrated under reduced pressure
  6. customthe resultant residue was purified by column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-ad4349523f614af097d0bd73d457fcbf
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723497

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