Dichloromethane → 3-[2(E)-(2-Pyridyl)ethenyl]benzyl alcohol

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

The methyl benzoate (Example 37b part ii) (2.25 g, 9.4 mmol) was dissolved in dry toluene (60 ml) and cooled to -70° C. under nitrogen. 1M DIBAL in dichloromethane (18.8 ml, 18.8 mmol) was added over 15 minutes and the reaction mixture allowed to warm up to -30° C. for 30 minutes. The reaction was quenched by careful addition of methanol (8 ml), then water, and after filtration through Celite the organic phase was evaporated in vacuo.

Herkunft & Nachweise