1-Methylpiperazine → methyl-5-(4-methyl-piperazin-1-yl)-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

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A solution of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 59 mg; 0.20 mmol) and 1-methylpiperazine (0.47 mL; 4.2 mmol) in N-methylpyrrolidinone (0.8 mL) was heated to 230° C. in a sealed vial under microwave irradiation for 2 hr. The mixture was allowed to cool to room temperature and the crude product was purified by reverse phase HPLC to provide methyl-5-(4-methyl-piperazin-1-yl)-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (41 mg, 57%) as an off white solid. ES-HRMS m/e calcd for C20H32N5O (M+H+) 358.2602, found 358.2597.

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