HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Water → 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Water | HCID 962 | — |
| Edukt | N-Bromomethylsaccharin | HCID 15225519 | — |
| Edukt | Methyltriazabicyclodecene | HCID 77320394 | — |
| Edukt | 2-Hydroxy-3-chloropyrido[1,2-a]pyrimidine-4-one | HCID 135758979 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin | HCID 10763054 | 65% |
Reaktionsschritte
To a mixture of 2-hydroxy-3-chloropyrido[1,2-a]pyrimidine-4-one (0.324 g), and methyltriazabicyclodecene (0.24 mL) in DMF (15 mL) was added 2-bromomethylsaccharin (0.414 g). The mixture was stirred overnight, poured into water and the precipitate which formed was collected by filtration and recrystallized from DMF to afford 0.371 g (65%) of 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05466701 |
| Quelldatensatz | uspto-grants-1995_11 |
| ORD ID | ord-bdefed0c38144a238c0018a84a3d9e58 |
| Quellennotiz | uspto-grants-1995_11 |