HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminothiazole → 5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Aminothiazole | HCID 2155 | — |
| Edukt | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Edukt | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| Edukt | 5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline | HCID 66998239 | — |
| Produkt | N-[5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732911 | 69% |
| Produkt | 5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene | HCID 66998975 | 539,3% |
Reaktionsschritte
5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene (0.91 g, 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 5-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.66 g, 81%) following general procedure C. N-[5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (1309, 69%) was prepared from 5-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (126 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07384967B2 |
| Quelldatensatz | uspto-grants-2008_06 |
| ORD ID | ord-867e53abdefb422fa7a085d135247e2b |
| Quellennotiz | uspto-grants-2008_06 |