HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Formylbenzoic acid → Tert-butyl 4-(4-formylbenzoyl)piperazine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Formylbenzoic acid | HCID 12088 | — |
| Edukt | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Edukt | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Edukt | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | Tert-butyl 4-(4-formylbenzoyl)piperazine-1-carboxylate | HCID 59218188 | — |
Reaktionsschritte
A suspension of 4-carboxybenzaldehyde (3.10 g) in CH2Cl2 was treated sequentially with piperazine-1-carboxylic acid tert-butyl ester (3.6 g), EDCl (3.86 g), HOBt (2.68 g), and 4-dimethylaminopyridine (˜0.020 g). After 18 h, the mixture was extracted with 1 N NaOH and then with 1 N HCl. The organic layer was dried (Na2SO4) and concentrated to yield the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07728129B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-9f2266dfe35b4b34a5f82d1e7a0771b8 |
| Quellennotiz | uspto-grants-2010_06 |