HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridine → n-(1h-Indol-7-yl)methanesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridine | HCID 1049 | — |
| Edukt | Methanesulfonyl chloride | HCID 31297 | — |
| Edukt | 7-Aminoindole | HCID 111634 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | n-(1h-Indol-7-yl)methanesulfonamide | HCID 20231824 | 94% |
Reaktionsschritte
Stir 1H-indol-7-ylamine with pyridine (1 equivalent) and methanesulfonyl chloride (1 equivalent) in dichloromethane for 12 hrs. Wash the reaction with 1N hydrochloric acid and water, dry over magnesium sulfate, and evaporate. Recrystallize the residue from isopropanol to obtain the title product as a purple solid (94%). MS (ES+), 210 (M), MS (ES−), 209 (M−1). LC/MS shows 95% purity.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07728150B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-54e3deaf4b5a4dd0936ca7f5174fa939 |
| Quellennotiz | uspto-grants-2010_06 |