HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → (4,4-Difluoro-piperidin-1-yl)-[5-[3-((2r,5r)-2,5-dimethyl-pyrrolidin-1-yl)-propoxy]-1h-pyrrolo[2,3-b]pyridin-2-yl]-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 2,5-Dimethylpyrrolidine, (2R,5R)- | HCID 641767 | — |
| Edukt | [5-(3-Chloro-propoxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 68424352 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | (4,4-Difluoro-piperidin-1-yl)-[5-[3-((2r,5r)-2,5-dimethyl-pyrrolidin-1-yl)-propoxy]-1h-pyrrolo[2,3-b]pyridin-2-yl]-methanone | HCID 16727338 | 6% |
Reaktionsschritte
The title compound was synthesized in analogy to example 1, intermediate a), from [5-(3-chloro-propoxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone, (2R,5R)-(−)-trans-2,5-dimethylpyrrolidine (commercially available) and potassium carbonate in acetonitrile to give 23 mg (6%) of the desired product as a light yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07622466B2 |
| Quelldatensatz | uspto-grants-2009_11 |
| ORD ID | ord-eaf599336a614d43b7b5c750f299e0fd |
| Quellennotiz | uspto-grants-2009_11 |