HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → (1-Aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-(3,4-dihydro-1H-isoquinolin-2-yl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | [4-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-6,7-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester | HCID 59341087 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | (1-Aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-(3,4-dihydro-1H-isoquinolin-2-yl)-methanone | HCID 46847057 | — |
Reaktionsschritte
A solution of [4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-6,7-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester (81 mg, 0.17 mmol) in 2 mL EtOAc was treated with HCl (6N in dioxane) according to Example 1 to give (1-Aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-(3,4-dihydro-1H-isoquinolin-2-yl)-methanone as the hydrochloride salt (77 mg, 93%). MS: APCI (M+H) calc'd for C22H23N3O3+H 378.4; found 378.1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732446B1 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-9d8bf6ead1224a43acb6e6f69687535e |
| Quellennotiz | uspto-grants-2010_06 |