HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tert-butyl 3-oxopyrrolidine-1-carboxylate → 3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tert-butyl 3-oxopyrrolidine-1-carboxylate | HCID 471360 | — |
| Edukt | 3-(2-Chloropyrimidin-4-yl)aniline | HCID 59341023 | — |
| Produkt | 3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86603246 | 70% |
Reaktionsschritte
Intermediate 6 was coupled with 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure J. The product was purified on silica gel using 1:1 ethyl acetate:hexanes as eluent. Yield: 70%. LC-MS showed the product had the expected M+H+ of 375.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732444B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-1fc235b6f85a43b4a99287ff419e95a2 |
| Quellennotiz | uspto-grants-2010_06 |