HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tetrafluoro-m-phenylenediamine dihydrochloride → (4r)-4-({4-[(2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-4,5-dihydro-7h-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Edukt | 2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde | HCID 248127 | — |
| Edukt | (4R)-4-[(4-amino-1-piperidinyl)methyl]-3-fluoro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one | HCID 68686964 | — |
| Produkt | (4r)-4-({4-[(2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-4,5-dihydro-7h-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride | HCID 68684837 | 71% |
Reaktionsschritte
The title compound was prepared from (4R)-4-[(4-amino-1-piperidinyl)methyl]-3-fluoro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one Enantiomer 1 and 2,3-dihydro-1,4-benzodioxin-6-carboxaldehyde (Aldrich) according to the general method of Example 2(h) (except that the dihydrochloride was prepared) in 71% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732461B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-2ed63c1b192a4d2ead674ec3f2add09b |
| Quellennotiz | uspto-grants-2010_06 |