HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrazine hydrate (1:1) → benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Edukt | 4-Piperidone | HCID 33721 | — |
| Edukt | Benzyl 2-Isopropyl-4-oxopiperidine-1-carboxylate | HCID 24213826 | — |
| Edukt | Benzyl 2-(4-chlorophenyl)-4-oxopiperidine-1-carboxylate | HCID 59342393 | — |
| Edukt | HCID 178418918 | HCID 178418918 | — |
| Produkt | benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate | HCID 68503449 | — |
Reaktionsschritte
Benzyl 2-isopropyl-4-oxopiperidine-1-carboxylate, prepared as described for compound 67 in Example 3 using isopropylmagnesium chloride, was formylated and treated with hydrazine hydrate as described for compound 50 in Example 1 to give benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate. This compound was then deprotected and treated with 4-chlorophenylsulfonyl chloride followed by NaOH as described for compound 52 in Example 1. The enantiomers were separated using HPLC Method [2].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732609B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-0d79eb667ed5444f8152a34c4d2c4fad |
| Quellennotiz | uspto-grants-2010_06 |