HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic Acid → 3-(3-Chloro-4-methoxy-benzylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | 3-Chloro-4-methoxybenzaldehyde | HCID 78619 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | HCID 178509242 | HCID 178509242 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Lösungsmittel | 1,3-Dimethyl-2-imidazolidinone | HCID 6661 | — |
| Produkt | 3-(3-Chloro-4-methoxy-benzylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine | HCID 19610550 | — |
Reaktionsschritte
Analogously to Example 21, 1.00 mmol of 3-amino-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine in 26 ml of methanol, 13 ml of DMEU and 3.0 mmol of acetic acid are first reacted with 3-chloro-4-methoxy-benzaldehyde and then reduced with 7.00 mmol of NaCNBH3 (5-7 days). 3-(3-Chloro-4-methoxy-benzylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine is obtained; m.p. 205-208° C.; HPLC: TRet (Grad20-100)=12.2.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05981533 |
| Quelldatensatz | uspto-grants-1999_11 |
| ORD ID | ord-9803bff3c783425c808218ddbf3b0f95 |
| Quellennotiz | uspto-grants-1999_11 |