1,4-dihydro-3H-2-benzopyran-3-one → (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzyl alcohol

https://huagongshe.com/de/reaction/1609307

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1,4-dihydro-3H-2-benzopyran-3-one	HCID 78092	—
Edukt	(E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine	HCID 15136086	—
Produkt	(E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzyl alcohol	HCID 44211474	—

Reaktionsschritte

A solution of 0.256 g of (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine and 0.148 g of 3-isochromanone was heated in a 126° C. oil bath for 17 hr. The residual materials were purified by silica gel chromatography using ethyl acetate-hexane (1:4 v/v) as the eluant to yield (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzyl alcohol.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05399702
Quelldatensatz	uspto-grants-1995_03
ORD ID	ord-976394392c5548f1b9eeac037a3d1c01
Quellennotiz	uspto-grants-1995_03