HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N,N,N-trimethylglycinium → (-)-Carnitine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N,N,N-trimethylglycinium | HCID 248 | — |
| Edukt | Carnitine Chloride | HCID 5970 | — |
| Edukt | (2R)-3-Cyano-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride | HCID 200829 | — |
| Lösungsmittel | Hydrochloric Acid | HCID 313 | — |
| Produkt | (-)-Carnitine | HCID 10917 | — |
Reaktionsschritte
13.5 kg L-carnitine nitrile chloride was dissolved in 22 liters concentrated hydrochloric acid and hydrolyzed to L-carnitine chloride, as described in Example 2. It was subsequently reacted to betaine in the highly basic ion exchanger (Amberlite IRA-416). After appropriate reprocessing, 11.1 kg colorless L-carnitine with (α)D20 =-30.8° and an HPLC concentration of 99.7% was isolated.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05191085 |
| Quelldatensatz | uspto-grants-1993_03 |
| ORD ID | ord-62087cc445b44d86996435c802aaa79a |
| Quellennotiz | uspto-grants-1993_03 |