Keto-pantoyllactone → D-Pantolactone

Beteiligte Stoffe

Reaktionsschritte

To 50 ml of benzene were added 12.8 g (100 m-mol) of ketopantolactone, 1 mg (0.0025 m-mol) of rhodium 1,5-hexadiene chloride complex compound and 3.0 mg (0.0055 m-mol) of (2S,4S)-N-methanesulfonyl-4-dicyclohexylphosphino-2-diphenylphosphinomethylpyrrolidine (MSCPM) obtained in Example 1(h). An autoclave equipped with a stirrer, a pressure gauge and a thermometer was charged with the above mixture and a treatment was carried out in the same manner as described in Example 13 whereby 12.4 g (yield: 95%) of D-pantolactone was obtained. [α]D =-42.1° (optical yield: 82.5%)

Herkunft & Nachweise