Hydrochloric Acid → N-[2-Amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine

https://huagongshe.com/de/reaction/16439

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Hydrochloric Acid	HCID 313	—
Edukt	Sodium Bicarbonate	HCID 516892	—
Edukt	4-((1H-Pyrrolo[2,3-B]pyridin-4-YL)oxy)-3-fluoroaniline	HCID 16037965	—
Edukt	4-Chloro-6-(pyridin-4-yl)pyrimidin-2-amine	HCID 22324286	—
Lösungsmittel	Water	HCID 962	—
Produkt	N-[2-Amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine	HCID 17979306	—

Reaktionsbedingungen

Temperatur	100 °C

Reaktionsschritte

55.6 mg (230 μmol) of 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline (from example XIX) are suspended in 5 ml of water. 47.2 mg (230 μmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX) and 0.01 ml of concentrated hydrochloric acid are added, and the mixture is stirred at 100° C. overnight. For work-up, the reaction solution is made alkaline using saturated sodium bicarbonate solution and extracted 3× with ethyl acetate, and the extracts are dried over sodium sulfate and concentrated using a rotary evaporator. The residue is purified by preparative HPLC.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07737153B2
Quelldatensatz	uspto-grants-2010_06
ORD ID	ord-3a76c860ad024c04852f4e10effe1bbe
Quellennotiz	uspto-grants-2010_06