HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 16440Erstellt: 24. Oktober 2026
Hydrochloric Acid → N-[2-Amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[2-fluoro-4-(1H-pyrrolo[2,3-b]-pyridin-4-yloxy)phenyl]amine
https://huagongshe.com/de/reaction/16440
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Edukt | 2-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline | HCID 17979351 | — |
| Edukt | 4-Chloro-6-(pyridin-4-yl)pyrimidin-2-amine | HCID 22324286 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | N-[2-Amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[2-fluoro-4-(1H-pyrrolo[2,3-b]-pyridin-4-yloxy)phenyl]amine | HCID 17979301 | — |
Reaktionsschritte
11 mg (50 μmol) of 2-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline (from example XX) are suspended in 5 ml of water. 9.3 mg (50 μmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX) and 0.01 ml of concentrated hydrochloric acid are added, and the mixture is stirred at 100° C. overnight. For work-up, the reaction solution is made alkaline with saturated sodium bicarbonate solution and extracted 3× with ethyl acetate, and the extracts are dried over sodium sulfate and concentrated using a rotary evaporator.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07737153B2 |
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| Quelldatensatz | uspto-grants-2010_06 |
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| ORD ID | ord-1a4f22055d7242a888e06591430201e8 |
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| Quellennotiz | uspto-grants-2010_06 |
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