4-Hydrazinobenzoic acid → 4-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid

Beteiligte Stoffe

Reaktionsschritte

To a suspension of 2.4 g (16 mmol) 4-hydrazino-benzoic acid in 12 mL toluene, 2.0 g of pivaloyl acetonitrile are added at rt. The suspension is heated to and kept under reflux for 12 h. After completion, the resulting reaction mixture is allowed to cool to rt. The precipitated product is isolated by filtration, washed with cold toluene and dried under high vacuum. [M+1]+=260.

Herkunft & Nachweise