HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Acetoxy-2-bromoethane → tert-butyl (2S,4R)-2-[(dimethylamino)carbonyl]-4-(2-ethoxy-2-oxo ethoxy)pyrrolidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Acetoxy-2-bromoethane | HCID 13564 | — |
| Edukt | tert-butyl (2S,4S)-2-(dimethylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate | HCID 67430109 | — |
| Produkt | tert-butyl (2S,4R)-2-[(dimethylamino)carbonyl]-4-(2-ethoxy-2-oxo ethoxy)pyrrolidine-1-carboxylate | HCID 67430579 | 46,1% |
Reaktionsschritte
With 20.0 g of tert-butyl (2S,4S)-2-[(dimethylamino)carbonyl]-4-hydroxypyrrolidine-1-carboxylate and 25.9 g of bromoethyl acetate as starting material, 12.3 g of the title compound obtained by a similar procedure to Step 139-1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08030499B2 |
| Quelldatensatz | uspto-grants-2011_10 |
| ORD ID | ord-e963e5333e174b09b5dbd2df29e79db1 |
| Quellennotiz | uspto-grants-2011_10 |