HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-l-amine → 6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-l-amine | HCID 67339476 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine | HCID 44478903 | — |
Reaktionsschritte
6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-1-amine (0.28 g, 0.81 mmol) was dissolved in ethanol (20 mL) and 10% palladium on carbon (0.086 g, 0.81 mmol) was added to the solution. The reaction stirred overnight at RT under a hydrogen atmosphere. The reaction was filtered through celite and concentrated to give the title compound as a pink film (0.25 g, 98%). MS (M+H)+ 318.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07989461B2 |
| Quelldatensatz | uspto-grants-2011_08 |
| ORD ID | ord-dcef76f14a72408db9f612a2eb14bbea |
| Quellennotiz | uspto-grants-2011_08 |