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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1668913Erstellt: 24. Oktober 2026

6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-l-amine → 6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine

https://huagongshe.com/de/reaction/1668913

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-l-amineHCID 67339476—
KatalysatorPalladiumHCID 23938—
LösungsmittelEthanolHCID 702—
Produkt6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamineHCID 44478903—

Reaktionsschritte

6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-1-amine (0.28 g, 0.81 mmol) was dissolved in ethanol (20 mL) and 10% palladium on carbon (0.086 g, 0.81 mmol) was added to the solution. The reaction stirred overnight at RT under a hydrogen atmosphere. The reaction was filtered through celite and concentrated to give the title compound as a pink film (0.25 g, 98%). MS (M+H)+ 318.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07989461B2
Quelldatensatzuspto-grants-2011_08
ORD IDord-dcef76f14a72408db9f612a2eb14bbea
Quellennotizuspto-grants-2011_08