HCID 18318790, Verbindung → Lorazepam

HRID 1700797

Reaktionsgleichung

Reaktionsgleichung von HRID 1700797
[CH:1]1[CH:2]=[CH:3][C:4]([Cl:21])=[C:5]([C:7]2[C:14]3[CH:15]=[C:16]([Cl:19])[CH:17]=[CH:18][C:13]=3[NH:12][C:10](=[O:11])[CH:9]([OH:20])[N:8]=2)[CH:6]=1.C(O)C>C(OCC)(=O)C>[CH:1]1[CH:2]=[CH:3][C:4]([Cl:21])=[C:5]([C:7]2[C:14]3[CH:15]=[C:16]([Cl:19])[CH:17]=[CH:18][C:13]=3[NH:12][C:10](=[O:11])[CH:9]([OH:20])[N:8]=2)[CH:6]=1

Komponenten

3

Edukt 1

HCID 18318790HCID 18318790, Verbindung

Produkt 1

HCID 3958LorazepamAusbeute 86,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Lorazepam ethanol solvate (5 kg) was suspended in ethyl acetate (20 L). The suspension was heated to 60° C. for one hour with rapid stirring and then cooled to 15° C. The suspension was filtered to recover the lorazepam crystals. The crystals were then washed with ethyl acetate (2L) and dried at 50° C. under 65 mm Hg vacuum for two hours to give crystalline lorazepam (3.8 kg, 80%).

Aufarbeitung

  1. temperaturecooled to 15° C
  2. filtrationThe suspension was filtered
  3. customto recover the lorazepam crystals
  4. washThe crystals were then washed with ethyl acetate (2L)
  5. customdried at 50° C. under 65 mm Hg vacuum for two hours

Quellen und Nachweise

ORD-Eintrag
ord-2de353c9f0d343dcbfef6e5e8a68ba67
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350870B2

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