HCID 18318790, Verbindung → Lorazepam

HRID 1700800

Reaktionsgleichung

Reaktionsgleichung von HRID 1700800
[CH:1]1[CH:2]=[CH:3][C:4]([Cl:21])=[C:5]([C:7]2[C:14]3[CH:15]=[C:16]([Cl:19])[CH:17]=[CH:18][C:13]=3[NH:12][C:10](=[O:11])[CH:9]([OH:20])[N:8]=2)[CH:6]=1.C(O)C>ClCCl>[CH:1]1[CH:2]=[CH:3][C:4]([Cl:21])=[C:5]([C:7]2[C:14]3[CH:15]=[C:16]([Cl:19])[CH:17]=[CH:18][C:13]=3[NH:12][C:10](=[O:11])[CH:9]([OH:20])[N:8]=2)[CH:6]=1

Komponenten

3

Edukt 1

HCID 18318790HCID 18318790, Verbindung

Produkt 1

HCID 3958LorazepamAusbeute 97,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

Lorazepam ethanol solvate (100 g) was suspended in dichloromethane (600 ml). The suspension was heated to about 40° C. for 1 hour with rapid stirring and then cooled to 10° C. The suspension was filtered to recover the lorazepam crystals. The crystals were washed with dichloromethane (20 ml) and dried at 50° C. under 65 mm Hg vacuum for two hours to give crystalline lorazepam (85.5 g, 90%).

Aufarbeitung

  1. temperaturecooled to 10° C
  2. filtrationThe suspension was filtered
  3. customto recover the lorazepam crystals
  4. washThe crystals were washed with dichloromethane (20 ml)
  5. customdried at 50° C. under 65 mm Hg vacuum for two hours

Quellen und Nachweise

ORD-Eintrag
ord-1583f4b3d10d448a81ae659cbb8f9ee0
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350870B2

Verknüpfte Notizen

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