HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Chloro-3-methoxypropane → Benzyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[1-(3-methoxypropyl)-1H-indol-4-ylmethoxy]piperidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Chloro-3-methoxypropane | HCID 118927 | — |
| Edukt | benzyl 3-(1H-indol-4-ylmethoxy)-4-{4-[3-(2-methoxy-benzyloxy)propoxy]phenyl}piperidine-1-carboxylate | HCID 68499385 | — |
| Produkt | Benzyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[1-(3-methoxypropyl)-1H-indol-4-ylmethoxy]piperidine-1-carboxylate | HCID 68502492 | — |
Reaktionsschritte
Analogously to Example 10a, 0.148 g of benzyl 3-(1H-indol-4-ylmethoxy)-4-{4-[3-(2-methoxy-benzyloxy)propoxy]phenyl}piperidine-1-carboxylate (Example 10b2) and 0.110 ml of 1-chloro-3-methoxypropane are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.25 (1:1 EtOAc-heptane); Rt=27.24 min (II).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07790715B2 |
| Quelldatensatz | uspto-grants-2010_09 |
| ORD ID | ord-8a5fdfa04af24477a48844a42f8cb888 |
| Quellennotiz | uspto-grants-2010_09 |