HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,4-Dioxane hydrochloride → (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Edukt | (S)-benzyl 2-(4-(tert-butoxycarbonylamino)phenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59396122 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59396116 | — |
Reaktionsschritte
To a solution of the Product from Example 3A (0.245 g, 0.56 mmol) in dioxane (5 mL) was added 4M HCl dioxane (2.8 mL, 11.2 mol) and the mixture was stirred at ambient temperature for 17 hours. The mixture was concentrated and azeotroped with toluene to five a tan solid (0.18 g, 86%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09163017B2 |
| Quelldatensatz | uspto-grants-2015_10 |
| ORD ID | ord-36f016a6f41b4814a42681bcb9c1d8d5 |
| Quellennotiz | uspto-grants-2015_10 |