4-Fluorophenol → 2-[3-(4-Fluorophenoxy)propyl]-5,7-bis(propan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared according to the experimentals described for Example 22 above from 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine and 2,6-dimethyl-3,5-heptanedione in 61% yield. The reagent 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine was prepared by a similar procedure for the synthesis of 3-[3-(4-chlorophenoxy)propyl]-1H-1,2,4-triazol-5-amine in Example 22 above, beginning from 4-fluorophenol instead of 4-chlorophenol. EM (calc.): 356.2; MS (ESI) m/e: 357.4 (M+H)+.

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